Energy-water-environment nexus is very important to attain COP21 goal, maintaining environment temperature increase below 2 °C, but unfortunately two third share of CO2 emission has already been used and the remaining will be exhausted by 2050. A number of technological developments in power and desalination sectors improved their efficiencies to save energy and carbon emission but still they are operating at 35% and 10% of their thermodynamic limits. Research in desalination processes contributing to fuel World population for their improved living standard and to reduce specific energy consumption and to protect environment. Recently developed highly efficient nature-inspired membranes (aquaporin & graphene) and trend in thermally driven cycle's hybridization could potentially lower then energy requirement for water purification. This paper presents a state of art review on energy, water and environment interconnection and future energy efficient desalination possibilities to save energy and protect environment.