TY - JOUR
T1 - Engineered biomimetic cell membrane-coated polymeric nanostructures for cancer therapy
AU - Faria, Marta
AU - Ferreira-Faria, Inês
AU - Sousa-Oliveira, Inês
AU - Pires, Patrícia C.
AU - Hameed, Huma
AU - Silva, Fernando
AU - Moço, Gabriela
AU - Ren, Juanna
AU - Zare, Ehsan Nazarzadeh
AU - Guo, Zhanhu
AU - Veiga, Francisco
AU - Makvandi, Pooyan
AU - Paiva-Santos, Ana Cláudia
PY - 2025/1
Y1 - 2025/1
N2 - Nanoparticle-based formulations have high-potential for cancer treatment and diagnosis owing to their high drug loading capacity, easy tunability, controlled cargo release and decreased nonspecific toxicity. However, they can be recognized by the immune system and be eliminated, thus compromising their effectiveness. To tackle this difficulty, cell membrane-coated nanoparticles (CMNPs) have emerged, which acquire various functions attributed to the biological cells from which they are obtained, such as prolonged circulation time, immune escape ability, and tumor targeting. However, CMNPs cannot improve the targetability and specificity of the nanosystems by 100 %. To circumvent this drawback, cell membrane engineering has been explored as a tool for refining the potential of the nanosystem, to assign new functions and to attach desired molecules to its surface, while maintaining the membrane's biological properties and biocompatibility intact.This review focuses on CMNPs, their synthesis methods and engineering strategies to enhance their functionality. Additionally, we explore the most recent progress in their biomedical applications, particularly in cancer therapy and diagnostics. This comprehensive evaluation highlights the potential of CMNPs as a versatile and innovate tool for advanced theranostics, while emphasizing the need for continued research to fully unlock their capabilities.
AB - Nanoparticle-based formulations have high-potential for cancer treatment and diagnosis owing to their high drug loading capacity, easy tunability, controlled cargo release and decreased nonspecific toxicity. However, they can be recognized by the immune system and be eliminated, thus compromising their effectiveness. To tackle this difficulty, cell membrane-coated nanoparticles (CMNPs) have emerged, which acquire various functions attributed to the biological cells from which they are obtained, such as prolonged circulation time, immune escape ability, and tumor targeting. However, CMNPs cannot improve the targetability and specificity of the nanosystems by 100 %. To circumvent this drawback, cell membrane engineering has been explored as a tool for refining the potential of the nanosystem, to assign new functions and to attach desired molecules to its surface, while maintaining the membrane's biological properties and biocompatibility intact.This review focuses on CMNPs, their synthesis methods and engineering strategies to enhance their functionality. Additionally, we explore the most recent progress in their biomedical applications, particularly in cancer therapy and diagnostics. This comprehensive evaluation highlights the potential of CMNPs as a versatile and innovate tool for advanced theranostics, while emphasizing the need for continued research to fully unlock their capabilities.
KW - Biomimetic
KW - Cell membrane coating
KW - Chemical engineering
KW - Chemical functionalization
KW - Polymeric nanoparticle
U2 - 10.1016/j.mtchem.2024.102506
DO - 10.1016/j.mtchem.2024.102506
M3 - Review article
AN - SCOPUS:85214403691
SN - 2468-5194
VL - 43
SP - 1
EP - 20
JO - Materials Today Chemistry
JF - Materials Today Chemistry
M1 - 102506
ER -