Estimation and determination of steroid solubility in supercritical carbon dioxide

John Dean; Mark Kane; Sharmin Khundker; Christopher Dowle; Roy Tranter; Peter Jones

doi:10.1039/an9952002153

Estimation and determination of steroid solubility in supercritical carbon dioxide

John Dean, Mark Kane, Sharmin Khundker, Christopher Dowle, Roy Tranter, Peter Jones

Applied Sciences Department

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The solubility of ten steroids in supercritical carbon dioxide is reported over a range of temperatures (35-100 °C) and pressures (84-231 kg cm -2). The solubility of testosterone, determined in this work, compares favourably with solubility data previously reported. The use of the solubility parameter and a hydrophobicity term (log P), has been shown to provide a qualitative estimate of steroid solubility.

Original language	English
Pages (from-to)	2153-2157
Journal	The Analyst
Volume	120
Issue number	8
DOIs	https://doi.org/10.1039/an9952002153
Publication status	Published - 1995

Keywords

Hydrophobicity
Log P
solubility parameter
solubility prediction
steroid solubility
supercritical carbon dioxide

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10.1039/an9952002153

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title = "Estimation and determination of steroid solubility in supercritical carbon dioxide",

abstract = "The solubility of ten steroids in supercritical carbon dioxide is reported over a range of temperatures (35-100 °C) and pressures (84-231 kg cm -2). The solubility of testosterone, determined in this work, compares favourably with solubility data previously reported. The use of the solubility parameter and a hydrophobicity term (log P), has been shown to provide a qualitative estimate of steroid solubility.",

keywords = "Hydrophobicity, Log P, solubility parameter, solubility prediction, steroid solubility, supercritical carbon dioxide",

author = "John Dean and Mark Kane and Sharmin Khundker and Christopher Dowle and Roy Tranter and Peter Jones",

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T1 - Estimation and determination of steroid solubility in supercritical carbon dioxide

AU - Dean, John

AU - Kane, Mark

AU - Khundker, Sharmin

AU - Dowle, Christopher

AU - Tranter, Roy

AU - Jones, Peter

PY - 1995

Y1 - 1995

N2 - The solubility of ten steroids in supercritical carbon dioxide is reported over a range of temperatures (35-100 °C) and pressures (84-231 kg cm -2). The solubility of testosterone, determined in this work, compares favourably with solubility data previously reported. The use of the solubility parameter and a hydrophobicity term (log P), has been shown to provide a qualitative estimate of steroid solubility.

AB - The solubility of ten steroids in supercritical carbon dioxide is reported over a range of temperatures (35-100 °C) and pressures (84-231 kg cm -2). The solubility of testosterone, determined in this work, compares favourably with solubility data previously reported. The use of the solubility parameter and a hydrophobicity term (log P), has been shown to provide a qualitative estimate of steroid solubility.

KW - Hydrophobicity

KW - Log P

KW - solubility parameter

KW - solubility prediction

KW - steroid solubility

KW - supercritical carbon dioxide

U2 - 10.1039/an9952002153

DO - 10.1039/an9952002153

M3 - Article

SN - 0003-2654

VL - 120

SP - 2153

EP - 2157

JO - The Analyst

JF - The Analyst

IS - 8

ER -

Estimation and determination of steroid solubility in supercritical carbon dioxide

Abstract

Keywords

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