Evaluating cellular uptake of gold nanoparticles in HL-7702 and HepG2 cells for plasmonic photothermal therapy

Peng Wang, Qiang Wu, Fuyan Wang, Yaping Zhang, Tao Jiang, Chenjie Gu, Shuiping Huang, Hongxi Wang, Shizhong Bu, Jun Zhou

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
13 Downloads (Pure)

Abstract

A novel method is proposed for quantifying the Raman intensity as a function of gold mass in a single cell based on the Raman mapping and inductively coupled plasma-mass spectrometry techniques. And a high-efficiency plasmonic photothermal therapy has also been achieved by adjusting the laser wavelength, laser power and exposure time, resulting in most of the HL-7702 cells survive, whereas most of the HepG2 cells get damaged.
Original languageEnglish
Pages (from-to)2245-2259
JournalNanomedicine
Volume13
Issue number18
Early online date3 Oct 2018
DOIs
Publication statusE-pub ahead of print - 3 Oct 2018

Keywords

  • cellular uptake
  • human hepatic immortalized cell lines (HL-7702)
  • cytotoxicity
  • gold nanoparticles
  • human hepatocellular carcinoma cell lines (HepG2)
  • ICP-MS
  • plasmonic photothermal therapy
  • Raman mapping
  • Surface enhanced Raman scattering (SERS)

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