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Evaluating cellular uptake of gold nanoparticles in HL-7702 and HepG2 cells for plasmonic photothermal therapy

Peng Wang, Qiang Wu, Fuyan Wang, Yaping Zhang, Tao Jiang, Chenjie Gu, Shuiping Huang, Hongxi Wang, Shizhong Bu, Jun Zhou*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)
    27 Downloads (Pure)

    Abstract

    A novel method is proposed for quantifying the Raman intensity as a function of gold mass in a single cell based on the Raman mapping and inductively coupled plasma-mass spectrometry techniques. And a high-efficiency plasmonic photothermal therapy has also been achieved by adjusting the laser wavelength, laser power and exposure time, resulting in most of the HL-7702 cells survive, whereas most of the HepG2 cells get damaged.
    Original languageEnglish
    Pages (from-to)2245-2259
    JournalNanomedicine
    Volume13
    Issue number18
    Early online date3 Oct 2018
    DOIs
    Publication statusPublished - 2018

    UN SDGs

    This output contributes to the following UN Sustainable Development Goals (SDGs)

    1. SDG 3 - Good Health and Well-being
      SDG 3 Good Health and Well-being

    Keywords

    • cellular uptake
    • human hepatic immortalized cell lines (HL-7702)
    • cytotoxicity
    • gold nanoparticles
    • human hepatocellular carcinoma cell lines (HepG2)
    • ICP-MS
    • plasmonic photothermal therapy
    • Raman mapping
    • Surface enhanced Raman scattering (SERS)

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