Evaluating the acute contributions of dopaminergic replacement to gait with obstacles in parkinson's disease

Frederico Pieruccini-Faria*, Rodrigo Vitório, Quincy J. Almeida, C. R.A. Silveira, M. J.D. Caetano, F. Stella, Sebastião Gobbi, Lilian Teresa Bucken Gobbi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


The influence of dopaminergic replacement (DR) on gait in people with Parkinson's disease (PD) is well documented. However, little is known about the acute effects of dopamine on more complex locomotor tasks that require visual guidance to avoid obstacles during gait. The authors investigated the influence of DR on locomotor behavior in a task where movement planning and control might be challenged by the height of the obstacle. The PD group included patients diagnosed with idiopathic PD (n = 12), as well as healthy controls (n = 12). Patients walked and stepped over obstacles of different heights before (OFF) and after (ON) levodopa intake. Spatial adjustments were not modulated by DR, but the step time to perform these anticipatory gait adjustments was longer only in PD-OFF (compared with healthy controls) when approaching the highest obstacle, but not PD-ON. During the crossing phase, trail limb toe clearance of PD patients was shorter than healthy controls only during the OFF state. ON-OFF comparisons were significantly different only for the time to reach the lead foot clearance over the highest obstacle. In summary, DR partially improved movement slowness but did not directly affect movement amplitude of lower limb regulation in this gait task.

Original languageEnglish
Pages (from-to)369-380
Number of pages12
JournalJournal of Motor Behavior
Issue number5
Early online date8 Jul 2013
Publication statusPublished - 1 Sept 2013
Externally publishedYes


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