A novel hybrid multiuser detection scheme that jointly uses linear and nonlinear interference suppression techniques is developed for high-speed direct-sequence code-division multiple-access communications in multipath frequency-selective fading channels. The detector detects signals in a symbol-by-symbol style. Conventional decorrelating detectors suffer from the noise enhancement problem, which becomes more serious for dispersive multipath channels. The proposed detector uses interference cancellation technology to reduce the rank of the expanded signal subspace and hence it preserves the advantages of the expanded decorrelating detector in terms of complete multiple access interference and intersymbol interference suppression and meanwhile avoids its disadvantage in terms of noise enhancement. Computer simulation shows clear superiority of the new detector to other existing methods.