Experimental design approach for supercritical fluid extraction

Mark Kane; John Dean; Steven Hitchen; Christopher Dowle; Roy Tranter

doi:10.1016/0003-2670(93)80555-Y

Experimental design approach for supercritical fluid extraction

Mark Kane, John Dean, Steven Hitchen, Christopher Dowle, Roy Tranter

Applied Sciences Department

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Experimental design with multilinear regression has been used to examine the relative contribution of the main experimental variables during supercritical fluid extraction. Six steroidal compounds of various solubilities in supercritical CO2 were considered. The results indicate that the density of the supercritical fluid has the greatest effect on the solubilisation and transfer of steroid from extraction cell to collection device. The minimum number of cell volumes of supercritical CO2 required for effective extraction was experimentally determined.

Original language	English
Pages (from-to)	83-90
Journal	Analytica Chimica Acta
Volume	271
Issue number	1
DOIs	https://doi.org/10.1016/0003-2670(93)80555-Y
Publication status	Published - Jan 1993

Keywords

Carbon dioxide
Extraction
Multilinear regression
Steroid
Supercritical fluid extraction

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10.1016/0003-2670(93)80555-Y

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abstract = "Experimental design with multilinear regression has been used to examine the relative contribution of the main experimental variables during supercritical fluid extraction. Six steroidal compounds of various solubilities in supercritical CO2 were considered. The results indicate that the density of the supercritical fluid has the greatest effect on the solubilisation and transfer of steroid from extraction cell to collection device. The minimum number of cell volumes of supercritical CO2 required for effective extraction was experimentally determined.",

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KW - Carbon dioxide

KW - Extraction

KW - Multilinear regression

KW - Steroid

KW - Supercritical fluid extraction

U2 - 10.1016/0003-2670(93)80555-Y

DO - 10.1016/0003-2670(93)80555-Y

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JO - Analytica Chimica Acta

JF - Analytica Chimica Acta

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Experimental design approach for supercritical fluid extraction

Abstract

Keywords

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