TY - JOUR
T1 - Exposure levels and health implications of fungicides, neonicotinoid insecticides, triazine herbicides and their associated metabolites in pregnant women and men
AU - Shang, Nanxiu
AU - Yang, Yingying
AU - Xiao, Yilin
AU - Wu, Yukang
AU - Li, Kaixuan
AU - Jiang, Xiaoman
AU - Sanganyado, Edmond
AU - Zhang, Qing
AU - Xia, Xinghui
N1 - Funding information: This work was jointly supported by the National Natural Science Foundation of China [grant number 42277008] and Fundamental Research Funds for the Cent Uiversities [grant number 2021NTST23].
PY - 2024/2/1
Y1 - 2024/2/1
N2 - Exposure to pesticides can pose a series of advance effects on human health. However, the exposure levels and health implications of the current use pesticides and their metabolites in both men and pregnant women remain unclear. In this study, an analytical method was developed to quantify fungicides, neonicotinoid insecticides, triazine herbicides, and their metabolites in the human serum. Fifty of the 73 target pesticides and metabolites were detected in the human serum of men and pregnant women from Wuxi, China, which included 11 triazine herbicides and metabolites, 17 neonicotinoid insecticides and metabolites, and 22 fungicides. Fungicides had the highest cumulative concentration (49.5 ng/mL), followed by neonicotinoid insecticides and metabolites (6.38 ng/mL), and triazine herbicides and metabolites (5.10 ng/mL). Moreover, the estimated daily intake (EDI) of fungicides was 10.4 and 12.7 times higher than that of triazine herbicides (included their metabolites) and neonicotinoid insecticides (included their metabolites), respectively. Of the three categories of pesticides, exposure to fungicides contributed to the highest exposure risk within the hazard quotient in the range of 5.1 × 10 -0.17. Correlation analysis revealed that the pesticide exposure levels in human serum were correlated with their maximum residue levels in vegetables and fruits. Pesticide exposure has also been correlated with the weight and Body Mass Index (BMI) of humans based on structural equation modeling. This study provides new insights into the exposure of men and pregnant women to a cocktail of fungicides, neonicotinoid insecticides, triazine herbicides and their metabolites.
AB - Exposure to pesticides can pose a series of advance effects on human health. However, the exposure levels and health implications of the current use pesticides and their metabolites in both men and pregnant women remain unclear. In this study, an analytical method was developed to quantify fungicides, neonicotinoid insecticides, triazine herbicides, and their metabolites in the human serum. Fifty of the 73 target pesticides and metabolites were detected in the human serum of men and pregnant women from Wuxi, China, which included 11 triazine herbicides and metabolites, 17 neonicotinoid insecticides and metabolites, and 22 fungicides. Fungicides had the highest cumulative concentration (49.5 ng/mL), followed by neonicotinoid insecticides and metabolites (6.38 ng/mL), and triazine herbicides and metabolites (5.10 ng/mL). Moreover, the estimated daily intake (EDI) of fungicides was 10.4 and 12.7 times higher than that of triazine herbicides (included their metabolites) and neonicotinoid insecticides (included their metabolites), respectively. Of the three categories of pesticides, exposure to fungicides contributed to the highest exposure risk within the hazard quotient in the range of 5.1 × 10 -0.17. Correlation analysis revealed that the pesticide exposure levels in human serum were correlated with their maximum residue levels in vegetables and fruits. Pesticide exposure has also been correlated with the weight and Body Mass Index (BMI) of humans based on structural equation modeling. This study provides new insights into the exposure of men and pregnant women to a cocktail of fungicides, neonicotinoid insecticides, triazine herbicides and their metabolites.
KW - Pesticides and their metabolites
KW - Human serum
KW - Human Exposure
KW - Risk assessment
UR - http://www.scopus.com/inward/record.url?scp=85178587247&partnerID=8YFLogxK
U2 - 10.1016/j.envpol.2023.123069
DO - 10.1016/j.envpol.2023.123069
M3 - Article
SN - 0269-7491
VL - 342
JO - Environmental Pollution
JF - Environmental Pollution
M1 - 123069
ER -