Expression of the MtsA lipoprotein of Streptococcus agalactiae A909 is regulated by manganese and iron

Beverley Bray, Iain Sutcliffe, Dean Harrington

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Metal ion acquisition and homeostasis are essential for bacterial survival, growth and physiology. A family of metal ion, ABC-type import systems have been identified in Gram-positive bacteria, in which the solute-binding proteins are predicted to be membrane-anchored lipoproteins. The prediction that the MtsA protein of Streptococcus agalactiae A909 is a lipoprotein was confirmed. The expression of MtsA was co-ordinately regulated by the presence of both manganese and ferrous ions suggesting that MtsA may be involved in the uptake of both these ions. MtsA was shown to be expressed at levels of ferrous ions known to be present in amniotic fluid, a growth medium for S. agalactiae during neonatal infection
Original languageEnglish
Pages (from-to)101-109
JournalAntonie van Leeuwenhoek
Volume95
Issue number1
DOIs
Publication statusPublished - Jan 2009

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