TY - JOUR
T1 - Expression of the MtsA lipoprotein of Streptococcus agalactiae A909 is regulated by manganese and iron
AU - Bray, Beverley
AU - Sutcliffe, Iain
AU - Harrington, Dean
PY - 2009/1
Y1 - 2009/1
N2 - Metal ion acquisition and homeostasis are essential for bacterial survival, growth and physiology. A family of metal ion, ABC-type import systems have been identified in Gram-positive bacteria, in which the solute-binding proteins are predicted to be membrane-anchored lipoproteins. The prediction that the MtsA protein of Streptococcus agalactiae A909 is a lipoprotein was confirmed. The expression of MtsA was co-ordinately regulated by the presence of both manganese and ferrous ions suggesting that MtsA may be involved in the uptake of both these ions. MtsA was shown to be expressed at levels of ferrous ions known to be present in amniotic fluid, a growth medium for S. agalactiae during neonatal infection
AB - Metal ion acquisition and homeostasis are essential for bacterial survival, growth and physiology. A family of metal ion, ABC-type import systems have been identified in Gram-positive bacteria, in which the solute-binding proteins are predicted to be membrane-anchored lipoproteins. The prediction that the MtsA protein of Streptococcus agalactiae A909 is a lipoprotein was confirmed. The expression of MtsA was co-ordinately regulated by the presence of both manganese and ferrous ions suggesting that MtsA may be involved in the uptake of both these ions. MtsA was shown to be expressed at levels of ferrous ions known to be present in amniotic fluid, a growth medium for S. agalactiae during neonatal infection
KW - Streptococcus agalactiae
KW - Lipoproteins
UR - https://www.scopus.com/pages/publications/57149091535
U2 - 10.1007/s10482-008-9291-6
DO - 10.1007/s10482-008-9291-6
M3 - Article
SN - 0003-6072
VL - 95
SP - 101
EP - 109
JO - Antonie van Leeuwenhoek
JF - Antonie van Leeuwenhoek
IS - 1
ER -