Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomised controlled trial

Andrew Pipingas; Andrew Sinclair; Kevin D. Croft; Andrzej S. Januszewski; Alicia J. Jenkins; Trevor A. Mori; Robyn Cockerell; Natalia A. Grima; Con Stough; Andrew Scholey; Stephen P. Myers; Avni Sali; Matthew P. Pase

doi:10.1016/j.jff.2014.10.028

Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomised controlled trial

Andrew Pipingas^*, Andrew Sinclair, Kevin D. Croft, Andrzej S. Januszewski, Alicia J. Jenkins, Trevor A. Mori, Robyn Cockerell, Natalia A. Grima, Con Stough, Andrew Scholey, Stephen P. Myers, Avni Sali, Matthew P. Pase

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The effects of daily fish oil supplementation, with and without multivitamins, on biochemical markers of health were examined. Healthy adults (N = 160) were randomised to receive 3 g of salmon oil with a multivitamin, 6 g of salmon oil with a multivitamin, 6 g of salmon oil in isolation or placebo in a double-blind fashion on a daily basis for 16 weeks. Relative to placebo, both 6 g salmon oil groups displayed significantly lower F2-isoprostane levels at endpoint. Increases in red blood cell polyunsaturated fatty acids correlated with reductions in F2-isoprostanes. Treatment had no effect on inflammatory cytokines, C-reactive protein, fibrinogen, cholesterol or triacylglycerol.

Original language	English
Pages (from-to)	949-957
Number of pages	9
Journal	Journal of Functional Foods
Volume	19
DOIs	https://doi.org/10.1016/j.jff.2014.10.028
Publication status	Published - 1 Dec 2015
Externally published	Yes

Keywords

F2-isoprostanes
Oxidative stress
Inflammation
Multivitamins
PUFA
Fish oil

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10.1016/j.jff.2014.10.028

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Pipingas, A., Sinclair, A., Croft, K. D., Januszewski, A. S., Jenkins, A. J., Mori, T. A., Cockerell, R., Grima, N. A., Stough, C., Scholey, A., Myers, S. P., Sali, A., & Pase, M. P. (2015). Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomised controlled trial. Journal of Functional Foods, 19, 949-957. https://doi.org/10.1016/j.jff.2014.10.028

@article{cf690f8b1346413c87183aca61f2e48a,

title = "Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomised controlled trial",

abstract = "The effects of daily fish oil supplementation, with and without multivitamins, on biochemical markers of health were examined. Healthy adults (N = 160) were randomised to receive 3 g of salmon oil with a multivitamin, 6 g of salmon oil with a multivitamin, 6 g of salmon oil in isolation or placebo in a double-blind fashion on a daily basis for 16 weeks. Relative to placebo, both 6 g salmon oil groups displayed significantly lower F2-isoprostane levels at endpoint. Increases in red blood cell polyunsaturated fatty acids correlated with reductions in F2-isoprostanes. Treatment had no effect on inflammatory cytokines, C-reactive protein, fibrinogen, cholesterol or triacylglycerol. ",

keywords = "F2-isoprostanes, Oxidative stress, Inflammation, Multivitamins, PUFA, Fish oil",

author = "Andrew Pipingas and Andrew Sinclair and Croft, \{Kevin D.\} and Januszewski, \{Andrzej S.\} and Jenkins, \{Alicia J.\} and Mori, \{Trevor A.\} and Robyn Cockerell and Grima, \{Natalia A.\} and Con Stough and Andrew Scholey and Myers, \{Stephen P.\} and Avni Sali and Pase, \{Matthew P.\}",

year = "2015",

month = dec,

day = "1",

doi = "10.1016/j.jff.2014.10.028",

language = "English",

volume = "19",

pages = "949--957",

journal = "Journal of Functional Foods",

issn = "1756-4646",

publisher = "Elsevier",

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Pipingas, A, Sinclair, A, Croft, KD, Januszewski, AS, Jenkins, AJ, Mori, TA, Cockerell, R, Grima, NA, Stough, C, Scholey, A, Myers, SP, Sali, A & Pase, MP 2015, 'Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomised controlled trial', Journal of Functional Foods, vol. 19, pp. 949-957. https://doi.org/10.1016/j.jff.2014.10.028

TY - JOUR

T1 - Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomised controlled trial

AU - Pipingas, Andrew

AU - Sinclair, Andrew

AU - Croft, Kevin D.

AU - Januszewski, Andrzej S.

AU - Jenkins, Alicia J.

AU - Mori, Trevor A.

AU - Cockerell, Robyn

AU - Grima, Natalia A.

AU - Stough, Con

AU - Scholey, Andrew

AU - Myers, Stephen P.

AU - Sali, Avni

AU - Pase, Matthew P.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The effects of daily fish oil supplementation, with and without multivitamins, on biochemical markers of health were examined. Healthy adults (N = 160) were randomised to receive 3 g of salmon oil with a multivitamin, 6 g of salmon oil with a multivitamin, 6 g of salmon oil in isolation or placebo in a double-blind fashion on a daily basis for 16 weeks. Relative to placebo, both 6 g salmon oil groups displayed significantly lower F2-isoprostane levels at endpoint. Increases in red blood cell polyunsaturated fatty acids correlated with reductions in F2-isoprostanes. Treatment had no effect on inflammatory cytokines, C-reactive protein, fibrinogen, cholesterol or triacylglycerol.

AB - The effects of daily fish oil supplementation, with and without multivitamins, on biochemical markers of health were examined. Healthy adults (N = 160) were randomised to receive 3 g of salmon oil with a multivitamin, 6 g of salmon oil with a multivitamin, 6 g of salmon oil in isolation or placebo in a double-blind fashion on a daily basis for 16 weeks. Relative to placebo, both 6 g salmon oil groups displayed significantly lower F2-isoprostane levels at endpoint. Increases in red blood cell polyunsaturated fatty acids correlated with reductions in F2-isoprostanes. Treatment had no effect on inflammatory cytokines, C-reactive protein, fibrinogen, cholesterol or triacylglycerol.

KW - F2-isoprostanes

KW - Oxidative stress

KW - Inflammation

KW - Multivitamins

KW - PUFA

KW - Fish oil

UR - https://www.scopus.com/pages/publications/84948682324

U2 - 10.1016/j.jff.2014.10.028

DO - 10.1016/j.jff.2014.10.028

M3 - Article

SN - 1756-4646

VL - 19

SP - 949

EP - 957

JO - Journal of Functional Foods

JF - Journal of Functional Foods

ER -

Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomised controlled trial

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Keywords

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