Fluorescent composite scaffolds made of nanodiamonds/polycaprolactone

Li Cao; Yanwen Hou; Khalid Lafdi; Kirk Urmey

doi:10.1016/j.cplett.2015.10.037

Fluorescent composite scaffolds made of nanodiamonds/polycaprolactone

Li Cao, Yanwen Hou, Khalid Lafdi, Kirk Urmey

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Polycaprolactone (PCL) has been widely studied for biological applications. Biodegradable PCL fibrous scaffold can work as an appropriate substrate for tissue regeneration. In this letter, fluorescent nanodiamonds (FNDs) were prepared after surface passivation with octadecylamine. The FNDs were then mixed with PCL polymer and subsequently electrospun into FNDs/PCL fibrous scaffolds. The obtained scaffolds not only exhibited photoluminescence, but also showed reinforced mechanical strength. Toxicity study indicated FNDs/PCL scaffolds were nontoxic. This biocompatible fluorescent composite fibrous scaffold can support in vitro cell growth and also has the potential to act as an optical probe for tissue engineering application in vitro and in vivo.

Original language	English
Pages (from-to)	123-128
Number of pages	6
Journal	Chemical Physics Letters
Volume	641
Early online date	23 Oct 2015
DOIs	https://doi.org/10.1016/j.cplett.2015.10.037
Publication status	Published - 16 Nov 2015
Externally published	Yes

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10.1016/j.cplett.2015.10.037

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title = "Fluorescent composite scaffolds made of nanodiamonds/polycaprolactone",

abstract = "Polycaprolactone (PCL) has been widely studied for biological applications. Biodegradable PCL fibrous scaffold can work as an appropriate substrate for tissue regeneration. In this letter, fluorescent nanodiamonds (FNDs) were prepared after surface passivation with octadecylamine. The FNDs were then mixed with PCL polymer and subsequently electrospun into FNDs/PCL fibrous scaffolds. The obtained scaffolds not only exhibited photoluminescence, but also showed reinforced mechanical strength. Toxicity study indicated FNDs/PCL scaffolds were nontoxic. This biocompatible fluorescent composite fibrous scaffold can support in vitro cell growth and also has the potential to act as an optical probe for tissue engineering application in vitro and in vivo.",

author = "Li Cao and Yanwen Hou and Khalid Lafdi and Kirk Urmey",

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doi = "10.1016/j.cplett.2015.10.037",

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journal = "Chemical Physics Letters",

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T1 - Fluorescent composite scaffolds made of nanodiamonds/polycaprolactone

AU - Cao, Li

AU - Hou, Yanwen

AU - Lafdi, Khalid

AU - Urmey, Kirk

PY - 2015/11/16

Y1 - 2015/11/16

N2 - Polycaprolactone (PCL) has been widely studied for biological applications. Biodegradable PCL fibrous scaffold can work as an appropriate substrate for tissue regeneration. In this letter, fluorescent nanodiamonds (FNDs) were prepared after surface passivation with octadecylamine. The FNDs were then mixed with PCL polymer and subsequently electrospun into FNDs/PCL fibrous scaffolds. The obtained scaffolds not only exhibited photoluminescence, but also showed reinforced mechanical strength. Toxicity study indicated FNDs/PCL scaffolds were nontoxic. This biocompatible fluorescent composite fibrous scaffold can support in vitro cell growth and also has the potential to act as an optical probe for tissue engineering application in vitro and in vivo.

AB - Polycaprolactone (PCL) has been widely studied for biological applications. Biodegradable PCL fibrous scaffold can work as an appropriate substrate for tissue regeneration. In this letter, fluorescent nanodiamonds (FNDs) were prepared after surface passivation with octadecylamine. The FNDs were then mixed with PCL polymer and subsequently electrospun into FNDs/PCL fibrous scaffolds. The obtained scaffolds not only exhibited photoluminescence, but also showed reinforced mechanical strength. Toxicity study indicated FNDs/PCL scaffolds were nontoxic. This biocompatible fluorescent composite fibrous scaffold can support in vitro cell growth and also has the potential to act as an optical probe for tissue engineering application in vitro and in vivo.

U2 - 10.1016/j.cplett.2015.10.037

DO - 10.1016/j.cplett.2015.10.037

M3 - Article

SN - 0009-2614

VL - 641

SP - 123

EP - 128

JO - Chemical Physics Letters

JF - Chemical Physics Letters

ER -

Fluorescent composite scaffolds made of nanodiamonds/polycaprolactone

Abstract

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