Fluorogenic 7-azidocoumarin and 3/4-azidophthalimide derivatives as indicators of reductase activity in microorganisms

Valerie Chalansonnet, John Lowe, Sylvain Orenga, John D Perry, Shaun N. Robinson, Stephen P. Stanforth, Hannah E. Sykes, Thang V. Truong

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
15 Downloads (Pure)

Abstract

A series of fluorogenic heterocyclic azides were prepared and assessed as reductase substrates across a selection of Gram-negative and Gram-positive microorganisms. The majority of these azides showed similar activity profiles to nitroreductase substrates. Microorganisms that do not produce hydrogen sulfide reduced the azides, indicating reductase activity was not linked to hydrogen sulfide production.
Original languageEnglish
Pages (from-to)2354-2357
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume29
Issue number16
Early online date7 Jun 2019
DOIs
Publication statusPublished - 15 Aug 2019

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