Fluorogenic L-alanylaminopeptidase substrates derived from 6-amino-2-hetarylquinolines and 7-amino-3-hetarylcoumarins and their potential applications in diagnostic microbiology

Marie Cellier-Rastit, Arthur L. James, Sylvain Orenga, John D. Perry, Shaun Robinson, Graeme Turnbull, Steven Stanforth

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Abstract

Six novel fluorogenic enzyme substrates for detecting L-alanylaminopeptidase activity in microorganisms have been prepared and evaluated in Columbia agar media. The substrates are L-alanyl derivatives of 6-amino-2-hetarylquinolines and 7-amino-3-hetarylcoumarins. Both the quinoline and coumarin series of substrates produced fluorescence in the presence of Gram-negative microorganisms. In contrast, fluorescence generation in the presence of the Gram-positive microorganisms and yeasts was limited or absent.
Original languageEnglish
Pages (from-to)1227-1231
JournalBioorganic and Medicinal Chemistry Letters
Volume29
Issue number10
Early online date9 Mar 2019
DOIs
Publication statusPublished - 15 May 2019

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