Fluostatins C~E, novel members of the fluostatin family produced by Streptomyces sp. Acta 1383

Stefanie Baur; Jörg Niehaus; Amalia Karagouni; Efstathios Katsifas; Kalliopi Chalkou; Christos Maintanis; Amanda Jones; Michael Goodfellow; Alan Ward; Winfried Beil; Kathrin Schneider; Roderich Süssmuth; Hans-Peter Fiedler

doi:10.1038/ja.2006.41

Fluostatins C~E, novel members of the fluostatin family produced by Streptomyces sp. Acta 1383

Stefanie Baur, Jörg Niehaus, Amalia Karagouni, Efstathios Katsifas, Kalliopi Chalkou, Christos Maintanis, Amanda Jones, Michael Goodfellow, Alan Ward, Winfried Beil, Kathrin Schneider, Roderich Süssmuth, Hans-Peter Fiedler

Applied Sciences Department

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Three new members of the fluostatin family, fluostatins CE, were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptomyces and is closely related to type strains classified in the Streptomyces lavendulae 16S rRNA subclade. Fluostatins are named by their characteristic fluorenone chromophore. Fluostatin C shows moderate activity against selected human tumor cell lines.

Original language	English
Pages (from-to)	293-297
Journal	Journal of Antibiotics
Volume	59
DOIs	https://doi.org/10.1038/ja.2006.41
Publication status	Published - 2006

Keywords

streptomyces
fermentation

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10.1038/ja.2006.41

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title = "Fluostatins C~E, novel members of the fluostatin family produced by Streptomyces sp. Acta 1383",

abstract = "Three new members of the fluostatin family, fluostatins CE, were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptomyces and is closely related to type strains classified in the Streptomyces lavendulae 16S rRNA subclade. Fluostatins are named by their characteristic fluorenone chromophore. Fluostatin C shows moderate activity against selected human tumor cell lines.",

keywords = "streptomyces, fermentation",

author = "Stefanie Baur and J{\"o}rg Niehaus and Amalia Karagouni and Efstathios Katsifas and Kalliopi Chalkou and Christos Maintanis and Amanda Jones and Michael Goodfellow and Alan Ward and Winfried Beil and Kathrin Schneider and Roderich S{\"u}ssmuth and Hans-Peter Fiedler",

year = "2006",

doi = "10.1038/ja.2006.41",

language = "English",

volume = "59",

pages = "293--297",

journal = "Journal of Antibiotics",

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T1 - Fluostatins C~E, novel members of the fluostatin family produced by Streptomyces sp. Acta 1383

AU - Baur, Stefanie

AU - Niehaus, Jörg

AU - Karagouni, Amalia

AU - Katsifas, Efstathios

AU - Chalkou, Kalliopi

AU - Maintanis, Christos

AU - Jones, Amanda

AU - Goodfellow, Michael

AU - Ward, Alan

AU - Beil, Winfried

AU - Schneider, Kathrin

AU - Süssmuth, Roderich

AU - Fiedler, Hans-Peter

PY - 2006

Y1 - 2006

N2 - Three new members of the fluostatin family, fluostatins CE, were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptomyces and is closely related to type strains classified in the Streptomyces lavendulae 16S rRNA subclade. Fluostatins are named by their characteristic fluorenone chromophore. Fluostatin C shows moderate activity against selected human tumor cell lines.

AB - Three new members of the fluostatin family, fluostatins CE, were discovered in a culture filtrate extract of strain Acta 1383 during an HPLC screening program. The producing strain belongs to the genus Streptomyces and is closely related to type strains classified in the Streptomyces lavendulae 16S rRNA subclade. Fluostatins are named by their characteristic fluorenone chromophore. Fluostatin C shows moderate activity against selected human tumor cell lines.

KW - streptomyces

KW - fermentation

U2 - 10.1038/ja.2006.41

DO - 10.1038/ja.2006.41

M3 - Article

SN - 0021-8820

VL - 59

SP - 293

EP - 297

JO - Journal of Antibiotics

JF - Journal of Antibiotics

ER -

Fluostatins C~E, novel members of the fluostatin family produced by Streptomyces sp. Acta 1383

Abstract

Keywords

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