While policy recognises the need to facilitate university-industry technology transfer (UITT), international studies indicate that the setup and effectiveness of the associated instruments is highly context-specific. We examine the reorientation of Irish universities in the direction of facilitating UITT, with a substantive focus on the role of Ireland's technology transfer offices. This paper also questions how academic research is changing in line with policy rhetoric. We find that Irish university research and the management of its output are changing in a manner that is not incompatible with UITT, although with significant resource and skills constraints. These findings hold important lessons for national economic and innovation systems of comparable size, with a development trajectory shaped by foreign direct investment.