Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson's Disease

Rosie Morris; Sue Lord; Rachael A Lawson; Shirley Coleman; Brook Galna; Gordon W Duncan; Tien K Khoo; Alison J Yarnall; David J Burn; Lynn Rochester

doi:10.1093/gerona/glx071

Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson's Disease

Rosie Morris, Sue Lord, Rachael A Lawson, Shirley Coleman, Brook Galna, Gordon W Duncan, Tien K Khoo, Alison J Yarnall, David J Burn, Lynn Rochester

Sport Exercise and Rehabilitation Department

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

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Abstract

Background: Dementia is significant in Parkinson's disease (PD) with personal and socioeconomic impact. Early identification of risk is of upmost importance to optimize management. Gait precedes and predicts cognitive decline and dementia in older adults. We aimed to evaluate gait characteristics as predictors of cognitive decline in newly diagnosed PD.

Methods: One hundred and nineteen participants recruited at diagnosis were assessed at baseline, 18 and 36 months. Baseline gait was characterized by variables that mapped to five domains: pace, rhythm, variability, asymmetry, and postural control. Cognitive assessment included attention, fluctuating attention, executive function, visual memory, and visuospatial function. Mixed-effects models tested independent gait predictors of cognitive decline.

Results: Gait characteristics of pace, variability, and postural control predicted decline in fluctuating attention and visual memory, whereas baseline neuropsychological assessment performance did not predict decline.

Conclusions: This provides novel evidence for gait as a clinical biomarker for PD cognitive decline in early disease.

Original language	English
Pages (from-to)	1656-1662
Number of pages	7
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	72
Issue number	12
DOIs	https://doi.org/10.1093/gerona/glx071
Publication status	Published - 9 Nov 2017

Keywords

Aged
Cognition
Cognitive Dysfunction/etiology
Female
Gait
Humans
Male
Parkinson Disease/complications
Predictive Value of Tests

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10.1093/gerona/glx071Licence: CC BY

glx071Final published version, 441 KBLicence: CC BY

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Morris, R., Lord, S., Lawson, R. A., Coleman, S., Galna, B., Duncan, G. W., Khoo, T. K., Yarnall, A. J., Burn, D. J., & Rochester, L. (2017). Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson's Disease. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 72(12), 1656-1662. https://doi.org/10.1093/gerona/glx071

@article{500cf47dfd484e8191fe96c30215b37c,

title = "Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson's Disease",

abstract = "Background: Dementia is significant in Parkinson's disease (PD) with personal and socioeconomic impact. Early identification of risk is of upmost importance to optimize management. Gait precedes and predicts cognitive decline and dementia in older adults. We aimed to evaluate gait characteristics as predictors of cognitive decline in newly diagnosed PD.Methods: One hundred and nineteen participants recruited at diagnosis were assessed at baseline, 18 and 36 months. Baseline gait was characterized by variables that mapped to five domains: pace, rhythm, variability, asymmetry, and postural control. Cognitive assessment included attention, fluctuating attention, executive function, visual memory, and visuospatial function. Mixed-effects models tested independent gait predictors of cognitive decline.Results: Gait characteristics of pace, variability, and postural control predicted decline in fluctuating attention and visual memory, whereas baseline neuropsychological assessment performance did not predict decline.Conclusions: This provides novel evidence for gait as a clinical biomarker for PD cognitive decline in early disease.",

keywords = "Aged, Cognition, Cognitive Dysfunction/etiology, Female, Gait, Humans, Male, Parkinson Disease/complications, Predictive Value of Tests",

author = "Rosie Morris and Sue Lord and Lawson, {Rachael A} and Shirley Coleman and Brook Galna and Duncan, {Gordon W} and Khoo, {Tien K} and Yarnall, {Alison J} and Burn, {David J} and Lynn Rochester",

note = "{\textcopyright} The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America.",

year = "2017",

month = nov,

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doi = "10.1093/gerona/glx071",

language = "English",

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journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",

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Morris, R, Lord, S, Lawson, RA, Coleman, S, Galna, B, Duncan, GW, Khoo, TK, Yarnall, AJ, Burn, DJ & Rochester, L 2017, 'Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson's Disease', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 72, no. 12, pp. 1656-1662. https://doi.org/10.1093/gerona/glx071

TY - JOUR

T1 - Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson's Disease

AU - Morris, Rosie

AU - Lord, Sue

AU - Lawson, Rachael A

AU - Coleman, Shirley

AU - Galna, Brook

AU - Duncan, Gordon W

AU - Khoo, Tien K

AU - Yarnall, Alison J

AU - Burn, David J

AU - Rochester, Lynn

N1 - © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America.

PY - 2017/11/9

Y1 - 2017/11/9

N2 - Background: Dementia is significant in Parkinson's disease (PD) with personal and socioeconomic impact. Early identification of risk is of upmost importance to optimize management. Gait precedes and predicts cognitive decline and dementia in older adults. We aimed to evaluate gait characteristics as predictors of cognitive decline in newly diagnosed PD.Methods: One hundred and nineteen participants recruited at diagnosis were assessed at baseline, 18 and 36 months. Baseline gait was characterized by variables that mapped to five domains: pace, rhythm, variability, asymmetry, and postural control. Cognitive assessment included attention, fluctuating attention, executive function, visual memory, and visuospatial function. Mixed-effects models tested independent gait predictors of cognitive decline.Results: Gait characteristics of pace, variability, and postural control predicted decline in fluctuating attention and visual memory, whereas baseline neuropsychological assessment performance did not predict decline.Conclusions: This provides novel evidence for gait as a clinical biomarker for PD cognitive decline in early disease.

AB - Background: Dementia is significant in Parkinson's disease (PD) with personal and socioeconomic impact. Early identification of risk is of upmost importance to optimize management. Gait precedes and predicts cognitive decline and dementia in older adults. We aimed to evaluate gait characteristics as predictors of cognitive decline in newly diagnosed PD.Methods: One hundred and nineteen participants recruited at diagnosis were assessed at baseline, 18 and 36 months. Baseline gait was characterized by variables that mapped to five domains: pace, rhythm, variability, asymmetry, and postural control. Cognitive assessment included attention, fluctuating attention, executive function, visual memory, and visuospatial function. Mixed-effects models tested independent gait predictors of cognitive decline.Results: Gait characteristics of pace, variability, and postural control predicted decline in fluctuating attention and visual memory, whereas baseline neuropsychological assessment performance did not predict decline.Conclusions: This provides novel evidence for gait as a clinical biomarker for PD cognitive decline in early disease.

KW - Aged

KW - Cognition

KW - Cognitive Dysfunction/etiology

KW - Female

KW - Gait

KW - Humans

KW - Male

KW - Parkinson Disease/complications

KW - Predictive Value of Tests

U2 - 10.1093/gerona/glx071

DO - 10.1093/gerona/glx071

M3 - Article

C2 - 28472409

SN - 1079-5006

VL - 72

SP - 1656

EP - 1662

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 12

ER -

Gait Rather Than Cognition Predicts Decline in Specific Cognitive Domains in Early Parkinson's Disease

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