Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671

Hans-Peter Fiedler, Anke Dieter, Tobias Gulder, Inga Kajahn, Andreas Hamm, Roselyn Brown, Amanda Jones, Michael Goodfellow, Werner Müller, Gerhard Bringmann

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The new aromatic polyketides genoketide A1, genoketide A2 and prechrysophanol glucuronide are biosynthetic intermediates of the octaketide chrysophanol. They were isolated from the alkaliphilic strain Streptomyces sp. AK 671 together with the new metabolite chrysophanol glucuronide. The structures of the compounds were elucidated by mass spectrometry and NMR methods. Genoketide A2 exhibited a slight and prechrysophanol glucuronide a more pronounced inhibition of the proliferation of L5178y lymphoma cells.
Original languageEnglish
Pages (from-to)464-473
JournalJournal of Antibiotics
Volume61
DOIs
Publication statusPublished - Jul 2008

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