Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671

Hans-Peter Fiedler; Anke Dieter; Tobias Gulder; Inga Kajahn; Andreas Hamm; Roselyn Brown; Amanda Jones; Michael Goodfellow; Werner Müller; Gerhard Bringmann

doi:10.1038/ja.2008.63

Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671

Hans-Peter Fiedler, Anke Dieter, Tobias Gulder, Inga Kajahn, Andreas Hamm, Roselyn Brown, Amanda Jones, Michael Goodfellow, Werner Müller, Gerhard Bringmann

Applied Sciences Department

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The new aromatic polyketides genoketide A1, genoketide A2 and prechrysophanol glucuronide are biosynthetic intermediates of the octaketide chrysophanol. They were isolated from the alkaliphilic strain Streptomyces sp. AK 671 together with the new metabolite chrysophanol glucuronide. The structures of the compounds were elucidated by mass spectrometry and NMR methods. Genoketide A2 exhibited a slight and prechrysophanol glucuronide a more pronounced inhibition of the proliferation of L5178y lymphoma cells.

Original language	English
Pages (from-to)	464-473
Journal	Journal of Antibiotics
Volume	61
DOIs	https://doi.org/10.1038/ja.2008.63
Publication status	Published - Jul 2008

Keywords

Fermentation
Streptomyces

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10.1038/ja.2008.63

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title = "Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671",

abstract = "The new aromatic polyketides genoketide A1, genoketide A2 and prechrysophanol glucuronide are biosynthetic intermediates of the octaketide chrysophanol. They were isolated from the alkaliphilic strain Streptomyces sp. AK 671 together with the new metabolite chrysophanol glucuronide. The structures of the compounds were elucidated by mass spectrometry and NMR methods. Genoketide A2 exhibited a slight and prechrysophanol glucuronide a more pronounced inhibition of the proliferation of L5178y lymphoma cells.",

keywords = "Fermentation, Streptomyces",

author = "Hans-Peter Fiedler and Anke Dieter and Tobias Gulder and Inga Kajahn and Andreas Hamm and Roselyn Brown and Amanda Jones and Michael Goodfellow and Werner M{\"u}ller and Gerhard Bringmann",

year = "2008",

month = jul,

doi = "10.1038/ja.2008.63",

language = "English",

volume = "61",

pages = "464--473",

journal = "Journal of Antibiotics",

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T1 - Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671

AU - Fiedler, Hans-Peter

AU - Dieter, Anke

AU - Gulder, Tobias

AU - Kajahn, Inga

AU - Hamm, Andreas

AU - Brown, Roselyn

AU - Jones, Amanda

AU - Goodfellow, Michael

AU - Müller, Werner

AU - Bringmann, Gerhard

PY - 2008/7

Y1 - 2008/7

N2 - The new aromatic polyketides genoketide A1, genoketide A2 and prechrysophanol glucuronide are biosynthetic intermediates of the octaketide chrysophanol. They were isolated from the alkaliphilic strain Streptomyces sp. AK 671 together with the new metabolite chrysophanol glucuronide. The structures of the compounds were elucidated by mass spectrometry and NMR methods. Genoketide A2 exhibited a slight and prechrysophanol glucuronide a more pronounced inhibition of the proliferation of L5178y lymphoma cells.

AB - The new aromatic polyketides genoketide A1, genoketide A2 and prechrysophanol glucuronide are biosynthetic intermediates of the octaketide chrysophanol. They were isolated from the alkaliphilic strain Streptomyces sp. AK 671 together with the new metabolite chrysophanol glucuronide. The structures of the compounds were elucidated by mass spectrometry and NMR methods. Genoketide A2 exhibited a slight and prechrysophanol glucuronide a more pronounced inhibition of the proliferation of L5178y lymphoma cells.

KW - Fermentation

KW - Streptomyces

U2 - 10.1038/ja.2008.63

DO - 10.1038/ja.2008.63

M3 - Article

SN - 0021-8820

VL - 61

SP - 464

EP - 473

JO - Journal of Antibiotics

JF - Journal of Antibiotics

ER -

Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671

Abstract

Keywords

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