TY - JOUR
T1 - Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient
AU - Ramdhan, Nikhil Doorvesh
AU - Blom, Jochen
AU - Sutcliffe, Iain C.
AU - Pereira-Ribeiro, Paula Marcele Afonso
AU - Santos, Cintia Silva
AU - Mattos-Guaraldi, Ana Luiza
AU - Burkovski, Andreas
AU - Sangal, Vartul
PY - 2019/7/1
Y1 - 2019/7/1
N2 - The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.
AB - The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.
KW - Adenoid cystic carcinoma
KW - Corynebacterium diphtheriae
KW - invasive infection
KW - nontoxigenic
KW - virulence
U2 - 10.1016/j.nmni.2019.100544
DO - 10.1016/j.nmni.2019.100544
M3 - Article
SN - 2052-2975
VL - 30
JO - New Microbes and New Infections
JF - New Microbes and New Infections
M1 - 100544
ER -
