Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient

Nikhil Doorvesh Ramdhan, Jochen Blom, Iain C. Sutcliffe, Paula Marcele Afonso Pereira-Ribeiro, Cintia Silva Santos, Ana Luiza Mattos-Guaraldi, Andreas Burkovski, Vartul Sangal

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
15 Downloads (Pure)

Abstract

The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.
Original languageEnglish
Article number100544
Number of pages4
JournalNew Microbes and New Infections
Volume30
Early online date9 Apr 2019
DOIs
Publication statusPublished - 1 Jul 2019

Fingerprint

Dive into the research topics of 'Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient'. Together they form a unique fingerprint.

Cite this