Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient

Nikhil Doorvesh Ramdhan; Jochen Blom; Iain C. Sutcliffe; Paula Marcele Afonso Pereira-Ribeiro; Cintia Silva Santos; Ana Luiza Mattos-Guaraldi; Andreas Burkovski; Vartul Sangal

doi:10.1016/j.nmni.2019.100544

Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient

Nikhil Doorvesh Ramdhan, Jochen Blom, Iain C. Sutcliffe, Paula Marcele Afonso Pereira-Ribeiro, Cintia Silva Santos, Ana Luiza Mattos-Guaraldi, Andreas Burkovski, Vartul Sangal

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Abstract

The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.

Original language	English
Article number	100544
Number of pages	4
Journal	New Microbes and New Infections
Volume	30
Early online date	9 Apr 2019
DOIs	https://doi.org/10.1016/j.nmni.2019.100544
Publication status	Published - 1 Jul 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adenoid cystic carcinoma
Corynebacterium diphtheriae
invasive infection
nontoxigenic
virulence

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Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patientFinal published version, 153 KBLicence: CC BY-NC-ND

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title = "Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient",

abstract = "The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.",

keywords = "Adenoid cystic carcinoma, Corynebacterium diphtheriae, invasive infection, nontoxigenic, virulence",

author = "Ramdhan, \{Nikhil Doorvesh\} and Jochen Blom and Sutcliffe, \{Iain C.\} and Pereira-Ribeiro, \{Paula Marcele Afonso\} and Santos, \{Cintia Silva\} and Mattos-Guaraldi, \{Ana Luiza\} and Andreas Burkovski and Vartul Sangal",

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doi = "10.1016/j.nmni.2019.100544",

language = "English",

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TY - JOUR

T1 - Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient

AU - Ramdhan, Nikhil Doorvesh

AU - Blom, Jochen

AU - Sutcliffe, Iain C.

AU - Pereira-Ribeiro, Paula Marcele Afonso

AU - Santos, Cintia Silva

AU - Mattos-Guaraldi, Ana Luiza

AU - Burkovski, Andreas

AU - Sangal, Vartul

PY - 2019/7/1

Y1 - 2019/7/1

N2 - The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.

AB - The genome of a novel nontoxigenic Corynebacterium diphtheriae, strain 5015, isolated from a patient with adenoid cystic carcinoma was sequenced and compared with 117 publically available genomes. This strain is phylogenetically distinct and lacks virulence genes encoding the toxin, BigA and Sdr-like adhesins. Strain 5015 possesses spaD-type and spaH-type pilus gene clusters with a loss of some gene functions, and 31 unique genes that need molecular characterization to understand their potential role in virulence characteristics.

KW - Adenoid cystic carcinoma

KW - Corynebacterium diphtheriae

KW - invasive infection

KW - nontoxigenic

KW - virulence

UR - https://www.scopus.com/pages/publications/85064601190

U2 - 10.1016/j.nmni.2019.100544

DO - 10.1016/j.nmni.2019.100544

M3 - Article

SN - 2052-2975

VL - 30

JO - New Microbes and New Infections

JF - New Microbes and New Infections

M1 - 100544

ER -

Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient

Abstract

UN SDGs

Keywords

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