Treatment of people with glioblastoma multiforme requires a multidisciplinary team approach, in which the advanced nurse practitioner has a vital role. The prognosis for these patients is poor and the impact of the diagnosis on patients and caregivers can be devastating. A comprehensive care plan can guide the patient through the disease process and mitigate the impact on them and their family. A holistic approach considering physical, psychosocial and economic factors can be useful in delivering effective care. The aim of this paper is to explore a systematic approach to physical and psychosocial assessment through a description of the diagnosis, treatment and symptom management of glioblastoma multiforme. The paper also discusses the role of the advanced nurse practitioner in meeting patients' and caregivers' complex needs.