Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013

Hmwe Kyu; Christine Pinho; Joseph Wagner; Jonathan Brown; Amelia Bertozzi-Villa; Fiona Charlson; Luc Edgar Coffeng; Lalit Dandona; Holly Erskine; Alize Ferrari; Christina Fitzmaurice; Thomas Fleming; Mohammad Forouzanfar; Nicholas Graetz; Caterina Guinovart; Juanita Haagsma; Hideki Higashi; Nicholas Kassebaum; Heidi Larson; Stephen Lim; Ali Mokdad; Maziar Moradi-Lakeh; Shaun Odell; Gregory Roth; Peter Serina; Jeffrey Stanaway; Awoke Misganaw; Harvey Whiteford; Timothy Wolock; Sarah Wulf Hanson; Foad Abd-Allah; Semaw Abera; Laith Abu-Raddad; Fadia AlBuhairan; Azmeraw Amare; Carl Abelardo Antonio; Al Artaman; Suzanne Barker-Collo; Lope Barrero; Corina Benjet; Isabela Bensenor; Zulfiqar Bhutta; Boris Bikbov; Alexandra Brazinova; Ismael Campos-Nonato; Carlos Castañeda-Orjuela; Ferrán Catalá-López; Rajiv Chowdhury; Cyrus Cooper; John Crump; Rakhi Dandona; Louisa Degenhardt; Robert Dellavalle; Samath Dharmaratne; Emerito Jose Faraon; Valery Feigin; Thomas Fürst; Johanna Geleijnse; Bradford Gessner; Katherine Gibney; Atsushi Goto; David Gunnell; Graeme Hankey; Roderick Hay; John Hornberger; H. Dean Hosgood; Guoqing Hu; Kathryn Jacobsen; Sudha Jayaraman; Panniyammakal Jeemon; Jost Jonas; André Karch; Daniel Kim; Sungroul Kim; Yoshihiro Kokubo; Barthelemy Kuate Defo; Burcu Kucuk Bicer; G. Anil Kumar; Anders Larsson; Janet Leasher; Ricky Leung; Yongmei Li; Steven Lipshultz; Alan Lopez; Paulo Lotufo; Raimundas Lunevicius; Ronan Lyons; Marek Majdan; Reza Malekzadeh; Taufiq Mashal; Amanda Mason-Jones; Yohannes Adama Melaku; Ziad Memish; Walter Mendoza; Ted Miller; Charles Mock; Joseph Murray; Sandra Nolte; In-Hwan Oh; Bolajoko Olubukunola Olusanya; Katrina Ortblad; Eun-Kee Park; Angel Paternina Caicedo; Scott Patten; George Patton; David Pereira; Norberto Perico; Frédéric Piel; Suzanne Polinder; Svetlana Popova; Farshad Pourmalek; D. Alex Quistberg; Giuseppe Remuzzi; Alina Rodriguez; David Rojas-Rueda; Dietrich Rothenbacher; David Rothstein; Juan Sanabria; Itamar Santos; David Schwebel; Sadaf Sepanlou; Amira Shaheen; Rahman Shiri; Ivy Shiue; Vegard Skirbekk; Karen Sliwa; Chandrashekhar Sreeramareddy; Dan Stein; Timothy Steiner; Lars Jacob Stovner; Bryan Sykes; Karen Tabb; Abdullah Sulieman Terkawi; Alan Thomson; Andrew Thorne-Lyman; Jeffrey Allen Towbin; Kingsley Nnanna Ukwaja; Tommi Vasankari; Narayanaswamy Venketasubramanian; Vasiliy Victorovich Vlassov; Stein Emil Vollset; Elisabete Weiderpass; Robert Weintraub; Andrea Werdecker; James Wilkinson; Solomon Meseret Woldeyohannes; Charles Wolfe; Yuichiro Yano; Paul Yip; Naohiro Yonemoto; Seok-Jun Yoon; Mustafa Younis; Chuanhua Yu; Maysaa El Sayed Zaki; Mohsen Naghavi; Christopher Murray; Theo Vos

doi:10.1001/jamapediatrics.2015.4276

Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013

Hmwe Kyu, Christine Pinho, Joseph Wagner, Jonathan Brown, Amelia Bertozzi-Villa, Fiona Charlson, Luc Edgar Coffeng, Lalit Dandona, Holly Erskine, Alize Ferrari, Christina Fitzmaurice, Thomas Fleming, Mohammad Forouzanfar, Nicholas Graetz, Caterina Guinovart, Juanita Haagsma, Hideki Higashi, Nicholas Kassebaum, Heidi Larson, Stephen LimAli Mokdad, Maziar Moradi-Lakeh, Shaun Odell, Gregory Roth, Peter Serina, Jeffrey Stanaway, Awoke Misganaw, Harvey Whiteford, Timothy Wolock, Sarah Wulf Hanson, Foad Abd-Allah, Semaw Abera, Laith Abu-Raddad, Fadia AlBuhairan, Azmeraw Amare, Carl Abelardo Antonio, Al Artaman, Suzanne Barker-Collo, Lope Barrero, Corina Benjet, Isabela Bensenor, Zulfiqar Bhutta, Boris Bikbov, Alexandra Brazinova, Ismael Campos-Nonato, Carlos Castañeda-Orjuela, Ferrán Catalá-López, Rajiv Chowdhury, Cyrus Cooper, John Crump, Rakhi Dandona, Louisa Degenhardt, Robert Dellavalle, Samath Dharmaratne, Emerito Jose Faraon, Valery Feigin, Thomas Fürst, Johanna Geleijnse, Bradford Gessner, Katherine Gibney, Atsushi Goto, David Gunnell, Graeme Hankey, Roderick Hay, John Hornberger, H. Dean Hosgood, Guoqing Hu, Kathryn Jacobsen, Sudha Jayaraman, Panniyammakal Jeemon, Jost Jonas, André Karch, Daniel Kim, Sungroul Kim, Yoshihiro Kokubo, Barthelemy Kuate Defo, Burcu Kucuk Bicer, G. Anil Kumar, Anders Larsson, Janet Leasher, Ricky Leung, Yongmei Li, Steven Lipshultz, Alan Lopez, Paulo Lotufo, Raimundas Lunevicius, Ronan Lyons, Marek Majdan, Reza Malekzadeh, Taufiq Mashal, Amanda Mason-Jones, Yohannes Adama Melaku, Ziad Memish, Walter Mendoza, Ted Miller, Charles Mock, Joseph Murray, Sandra Nolte, In-Hwan Oh, Bolajoko Olubukunola Olusanya, Katrina Ortblad, Eun-Kee Park, Angel Paternina Caicedo, Scott Patten, George Patton, David Pereira, Norberto Perico, Frédéric Piel, Suzanne Polinder, Svetlana Popova, Farshad Pourmalek, D. Alex Quistberg, Giuseppe Remuzzi, Alina Rodriguez, David Rojas-Rueda, Dietrich Rothenbacher, David Rothstein, Juan Sanabria, Itamar Santos, David Schwebel, Sadaf Sepanlou, Amira Shaheen, Rahman Shiri, Ivy Shiue, Vegard Skirbekk, Karen Sliwa, Chandrashekhar Sreeramareddy, Dan Stein, Timothy Steiner, Lars Jacob Stovner, Bryan Sykes, Karen Tabb, Abdullah Sulieman Terkawi, Alan Thomson, Andrew Thorne-Lyman, Jeffrey Allen Towbin, Kingsley Nnanna Ukwaja, Tommi Vasankari, Narayanaswamy Venketasubramanian, Vasiliy Victorovich Vlassov, Stein Emil Vollset, Elisabete Weiderpass, Robert Weintraub, Andrea Werdecker, James Wilkinson, Solomon Meseret Woldeyohannes, Charles Wolfe, Yuichiro Yano, Paul Yip, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Younis, Chuanhua Yu, Maysaa El Sayed Zaki, Mohsen Naghavi, Christopher Murray, Theo Vos

Nursing Midwifery and Health Department

Research output: Contribution to journal › Article › peer-review

520 Citations (Scopus)

Abstract

Importance - The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. Objective - To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. Conclusions and Relevance - Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.

Original language	English
Pages (from-to)	267-287
Journal	JAMA Pediatrics
Volume	170
Issue number	3
Early online date	25 Jan 2016
DOIs	https://doi.org/10.1001/jamapediatrics.2015.4276
Publication status	E-pub ahead of print - 25 Jan 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1001/jamapediatrics.2015.4276

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Kyu, H., Pinho, C., Wagner, J., Brown, J., Bertozzi-Villa, A., Charlson, F., Coffeng, L. E., Dandona, L., Erskine, H., Ferrari, A., Fitzmaurice, C., Fleming, T., Forouzanfar, M., Graetz, N., Guinovart, C., Haagsma, J., Higashi, H., Kassebaum, N., Larson, H., ... Vos, T. (2016). Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013. JAMA Pediatrics, 170(3), 267-287. Advance online publication. https://doi.org/10.1001/jamapediatrics.2015.4276

@article{86b81dac663549a39c8123262dbbfc4f,

title = "Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013",

abstract = "Importance - The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. Objective - To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. Conclusions and Relevance - Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.",

author = "Hmwe Kyu and Christine Pinho and Joseph Wagner and Jonathan Brown and Amelia Bertozzi-Villa and Fiona Charlson and Coffeng, {Luc Edgar} and Lalit Dandona and Holly Erskine and Alize Ferrari and Christina Fitzmaurice and Thomas Fleming and Mohammad Forouzanfar and Nicholas Graetz and Caterina Guinovart and Juanita Haagsma and Hideki Higashi and Nicholas Kassebaum and Heidi Larson and Stephen Lim and Ali Mokdad and Maziar Moradi-Lakeh and Shaun Odell and Gregory Roth and Peter Serina and Jeffrey Stanaway and Awoke Misganaw and Harvey Whiteford and Timothy Wolock and {Wulf Hanson}, Sarah and Foad Abd-Allah and Semaw Abera and Laith Abu-Raddad and Fadia AlBuhairan and Azmeraw Amare and Antonio, {Carl Abelardo} and Al Artaman and Suzanne Barker-Collo and Lope Barrero and Corina Benjet and Isabela Bensenor and Zulfiqar Bhutta and Boris Bikbov and Alexandra Brazinova and Ismael Campos-Nonato and Carlos Casta{\~n}eda-Orjuela and Ferr{\'a}n Catal{\'a}-L{\'o}pez and Rajiv Chowdhury and Cyrus Cooper and John Crump and Rakhi Dandona and Louisa Degenhardt and Robert Dellavalle and Samath Dharmaratne and Faraon, {Emerito Jose} and Valery Feigin and Thomas F{\"u}rst and Johanna Geleijnse and Bradford Gessner and Katherine Gibney and Atsushi Goto and David Gunnell and Graeme Hankey and Roderick Hay and John Hornberger and Hosgood, {H. Dean} and Guoqing Hu and Kathryn Jacobsen and Sudha Jayaraman and Panniyammakal Jeemon and Jost Jonas and Andr{\'e} Karch and Daniel Kim and Sungroul Kim and Yoshihiro Kokubo and {Kuate Defo}, Barthelemy and {Kucuk Bicer}, Burcu and Kumar, {G. Anil} and Anders Larsson and Janet Leasher and Ricky Leung and Yongmei Li and Steven Lipshultz and Alan Lopez and Paulo Lotufo and Raimundas Lunevicius and Ronan Lyons and Marek Majdan and Reza Malekzadeh and Taufiq Mashal and Amanda Mason-Jones and Melaku, {Yohannes Adama} and Ziad Memish and Walter Mendoza and Ted Miller and Charles Mock and Joseph Murray and Sandra Nolte and In-Hwan Oh and Olusanya, {Bolajoko Olubukunola} and Katrina Ortblad and Eun-Kee Park and {Paternina Caicedo}, Angel and Scott Patten and George Patton and David Pereira and Norberto Perico and Fr{\'e}d{\'e}ric Piel and Suzanne Polinder and Svetlana Popova and Farshad Pourmalek and Quistberg, {D. Alex} and Giuseppe Remuzzi and Alina Rodriguez and David Rojas-Rueda and Dietrich Rothenbacher and David Rothstein and Juan Sanabria and Itamar Santos and David Schwebel and Sadaf Sepanlou and Amira Shaheen and Rahman Shiri and Ivy Shiue and Vegard Skirbekk and Karen Sliwa and Chandrashekhar Sreeramareddy and Dan Stein and Timothy Steiner and Stovner, {Lars Jacob} and Bryan Sykes and Karen Tabb and Terkawi, {Abdullah Sulieman} and Alan Thomson and Andrew Thorne-Lyman and Towbin, {Jeffrey Allen} and Ukwaja, {Kingsley Nnanna} and Tommi Vasankari and Narayanaswamy Venketasubramanian and Vlassov, {Vasiliy Victorovich} and Vollset, {Stein Emil} and Elisabete Weiderpass and Robert Weintraub and Andrea Werdecker and James Wilkinson and Woldeyohannes, {Solomon Meseret} and Charles Wolfe and Yuichiro Yano and Paul Yip and Naohiro Yonemoto and Seok-Jun Yoon and Mustafa Younis and Chuanhua Yu and {El Sayed Zaki}, Maysaa and Mohsen Naghavi and Christopher Murray and Theo Vos",

year = "2016",

month = jan,

day = "25",

doi = "10.1001/jamapediatrics.2015.4276",

language = "English",

volume = "170",

pages = "267--287",

journal = "JAMA Pediatrics",

issn = "2168-6203",

publisher = "American Medical Association",

number = "3",

}

Kyu, H, Pinho, C, Wagner, J, Brown, J, Bertozzi-Villa, A, Charlson, F, Coffeng, LE, Dandona, L, Erskine, H, Ferrari, A, Fitzmaurice, C, Fleming, T, Forouzanfar, M, Graetz, N, Guinovart, C, Haagsma, J, Higashi, H, Kassebaum, N, Larson, H, Lim, S, Mokdad, A, Moradi-Lakeh, M, Odell, S, Roth, G, Serina, P, Stanaway, J, Misganaw, A, Whiteford, H, Wolock, T, Wulf Hanson, S, Abd-Allah, F, Abera, S, Abu-Raddad, L, AlBuhairan, F, Amare, A, Antonio, CA, Artaman, A, Barker-Collo, S, Barrero, L, Benjet, C, Bensenor, I, Bhutta, Z, Bikbov, B, Brazinova, A, Campos-Nonato, I, Castañeda-Orjuela, C, Catalá-López, F, Chowdhury, R, Cooper, C, Crump, J, Dandona, R, Degenhardt, L, Dellavalle, R, Dharmaratne, S, Faraon, EJ, Feigin, V, Fürst, T, Geleijnse, J, Gessner, B, Gibney, K, Goto, A, Gunnell, D, Hankey, G, Hay, R, Hornberger, J, Hosgood, HD, Hu, G, Jacobsen, K, Jayaraman, S, Jeemon, P, Jonas, J, Karch, A, Kim, D, Kim, S, Kokubo, Y, Kuate Defo, B, Kucuk Bicer, B, Kumar, GA, Larsson, A, Leasher, J, Leung, R, Li, Y, Lipshultz, S, Lopez, A, Lotufo, P, Lunevicius, R, Lyons, R, Majdan, M, Malekzadeh, R, Mashal, T, Mason-Jones, A, Melaku, YA, Memish, Z, Mendoza, W, Miller, T, Mock, C, Murray, J, Nolte, S, Oh, I-H, Olusanya, BO, Ortblad, K, Park, E-K, Paternina Caicedo, A, Patten, S, Patton, G, Pereira, D, Perico, N, Piel, F, Polinder, S, Popova, S, Pourmalek, F, Quistberg, DA, Remuzzi, G, Rodriguez, A, Rojas-Rueda, D, Rothenbacher, D, Rothstein, D, Sanabria, J, Santos, I, Schwebel, D, Sepanlou, S, Shaheen, A, Shiri, R, Shiue, I, Skirbekk, V, Sliwa, K, Sreeramareddy, C, Stein, D, Steiner, T, Stovner, LJ, Sykes, B, Tabb, K, Terkawi, AS, Thomson, A, Thorne-Lyman, A, Towbin, JA, Ukwaja, KN, Vasankari, T, Venketasubramanian, N, Vlassov, VV, Vollset, SE, Weiderpass, E, Weintraub, R, Werdecker, A, Wilkinson, J, Woldeyohannes, SM, Wolfe, C, Yano, Y, Yip, P, Yonemoto, N, Yoon, S-J, Younis, M, Yu, C, El Sayed Zaki, M, Naghavi, M, Murray, C & Vos, T 2016, 'Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013', JAMA Pediatrics, vol. 170, no. 3, pp. 267-287. https://doi.org/10.1001/jamapediatrics.2015.4276

TY - JOUR

T1 - Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013

AU - Kyu, Hmwe

AU - Pinho, Christine

AU - Wagner, Joseph

AU - Brown, Jonathan

AU - Bertozzi-Villa, Amelia

AU - Charlson, Fiona

AU - Coffeng, Luc Edgar

AU - Dandona, Lalit

AU - Erskine, Holly

AU - Ferrari, Alize

AU - Fitzmaurice, Christina

AU - Fleming, Thomas

AU - Forouzanfar, Mohammad

AU - Graetz, Nicholas

AU - Guinovart, Caterina

AU - Haagsma, Juanita

AU - Higashi, Hideki

AU - Kassebaum, Nicholas

AU - Larson, Heidi

AU - Lim, Stephen

AU - Mokdad, Ali

AU - Moradi-Lakeh, Maziar

AU - Odell, Shaun

AU - Roth, Gregory

AU - Serina, Peter

AU - Stanaway, Jeffrey

AU - Misganaw, Awoke

AU - Whiteford, Harvey

AU - Wolock, Timothy

AU - Wulf Hanson, Sarah

AU - Abd-Allah, Foad

AU - Abera, Semaw

AU - Abu-Raddad, Laith

AU - AlBuhairan, Fadia

AU - Amare, Azmeraw

AU - Antonio, Carl Abelardo

AU - Artaman, Al

AU - Barker-Collo, Suzanne

AU - Barrero, Lope

AU - Benjet, Corina

AU - Bensenor, Isabela

AU - Bhutta, Zulfiqar

AU - Bikbov, Boris

AU - Brazinova, Alexandra

AU - Campos-Nonato, Ismael

AU - Castañeda-Orjuela, Carlos

AU - Catalá-López, Ferrán

AU - Chowdhury, Rajiv

AU - Cooper, Cyrus

AU - Crump, John

AU - Dandona, Rakhi

AU - Degenhardt, Louisa

AU - Dellavalle, Robert

AU - Dharmaratne, Samath

AU - Faraon, Emerito Jose

AU - Feigin, Valery

AU - Fürst, Thomas

AU - Geleijnse, Johanna

AU - Gessner, Bradford

AU - Gibney, Katherine

AU - Goto, Atsushi

AU - Gunnell, David

AU - Hankey, Graeme

AU - Hay, Roderick

AU - Hornberger, John

AU - Hosgood, H. Dean

AU - Hu, Guoqing

AU - Jacobsen, Kathryn

AU - Jayaraman, Sudha

AU - Jeemon, Panniyammakal

AU - Jonas, Jost

AU - Karch, André

AU - Kim, Daniel

AU - Kim, Sungroul

AU - Kokubo, Yoshihiro

AU - Kuate Defo, Barthelemy

AU - Kucuk Bicer, Burcu

AU - Kumar, G. Anil

AU - Larsson, Anders

AU - Leasher, Janet

AU - Leung, Ricky

AU - Li, Yongmei

AU - Lipshultz, Steven

AU - Lopez, Alan

AU - Lotufo, Paulo

AU - Lunevicius, Raimundas

AU - Lyons, Ronan

AU - Majdan, Marek

AU - Malekzadeh, Reza

AU - Mashal, Taufiq

AU - Mason-Jones, Amanda

AU - Melaku, Yohannes Adama

AU - Memish, Ziad

AU - Mendoza, Walter

AU - Miller, Ted

AU - Mock, Charles

AU - Murray, Joseph

AU - Nolte, Sandra

AU - Oh, In-Hwan

AU - Olusanya, Bolajoko Olubukunola

AU - Ortblad, Katrina

AU - Park, Eun-Kee

AU - Paternina Caicedo, Angel

AU - Patten, Scott

AU - Patton, George

AU - Pereira, David

AU - Perico, Norberto

AU - Piel, Frédéric

AU - Polinder, Suzanne

AU - Popova, Svetlana

AU - Pourmalek, Farshad

AU - Quistberg, D. Alex

AU - Remuzzi, Giuseppe

AU - Rodriguez, Alina

AU - Rojas-Rueda, David

AU - Rothenbacher, Dietrich

AU - Rothstein, David

AU - Sanabria, Juan

AU - Santos, Itamar

AU - Schwebel, David

AU - Sepanlou, Sadaf

AU - Shaheen, Amira

AU - Shiri, Rahman

AU - Shiue, Ivy

AU - Skirbekk, Vegard

AU - Sliwa, Karen

AU - Sreeramareddy, Chandrashekhar

AU - Stein, Dan

AU - Steiner, Timothy

AU - Stovner, Lars Jacob

AU - Sykes, Bryan

AU - Tabb, Karen

AU - Terkawi, Abdullah Sulieman

AU - Thomson, Alan

AU - Thorne-Lyman, Andrew

AU - Towbin, Jeffrey Allen

AU - Ukwaja, Kingsley Nnanna

AU - Vasankari, Tommi

AU - Venketasubramanian, Narayanaswamy

AU - Vlassov, Vasiliy Victorovich

AU - Vollset, Stein Emil

AU - Weiderpass, Elisabete

AU - Weintraub, Robert

AU - Werdecker, Andrea

AU - Wilkinson, James

AU - Woldeyohannes, Solomon Meseret

AU - Wolfe, Charles

AU - Yano, Yuichiro

AU - Yip, Paul

AU - Yonemoto, Naohiro

AU - Yoon, Seok-Jun

AU - Younis, Mustafa

AU - Yu, Chuanhua

AU - El Sayed Zaki, Maysaa

AU - Naghavi, Mohsen

AU - Murray, Christopher

AU - Vos, Theo

PY - 2016/1/25

Y1 - 2016/1/25

N2 - Importance - The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. Objective - To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. Conclusions and Relevance - Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.

AB - Importance - The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. Objective - To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. Conclusions and Relevance - Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.

U2 - 10.1001/jamapediatrics.2015.4276

DO - 10.1001/jamapediatrics.2015.4276

M3 - Article

SN - 2168-6203

VL - 170

SP - 267

EP - 287

JO - JAMA Pediatrics

JF - JAMA Pediatrics

IS - 3

ER -

Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013

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