Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis.

Vartul Sangal, Kathryn Holt, Jianfeng Yuan, Derek Brown, Ingrid Filliol-Toutain, François-Xavier Weill, Dong-Wook Kim, Wanderley Dias da Silveira, Derek Pickard, Nicholas Thomson, Julian Parkhill, Jun Yu

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.
Original languageEnglish
Pages (from-to)303-5
JournalJournal of Clinical Microbiology
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 2013

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