TY - JOUR
T1 - Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis.
AU - Sangal, Vartul
AU - Holt, Kathryn
AU - Yuan, Jianfeng
AU - Brown, Derek
AU - Filliol-Toutain, Ingrid
AU - Weill, François-Xavier
AU - Kim, Dong-Wook
AU - Dias da Silveira, Wanderley
AU - Pickard, Derek
AU - Thomson, Nicholas
AU - Parkhill, Julian
AU - Yu, Jun
PY - 2013/1
Y1 - 2013/1
N2 - The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.
AB - The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.
U2 - 10.1128/JCM.02238-12
DO - 10.1128/JCM.02238-12
M3 - Article
SN - 0095-1137
VL - 51
SP - 303
EP - 305
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 1
ER -