Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis.

Vartul Sangal; Kathryn Holt; Jianfeng Yuan; Derek Brown; Ingrid Filliol-Toutain; François-Xavier Weill; Dong-Wook Kim; Wanderley Dias da Silveira; Derek Pickard; Nicholas Thomson; Julian Parkhill; Jun Yu

doi:10.1128/JCM.02238-12

Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis.

Vartul Sangal, Kathryn Holt, Jianfeng Yuan, Derek Brown, Ingrid Filliol-Toutain, François-Xavier Weill, Dong-Wook Kim, Wanderley Dias da Silveira, Derek Pickard, Nicholas Thomson, Julian Parkhill, Jun Yu

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.

Original language	English
Pages (from-to)	303-5
Journal	Journal of Clinical Microbiology
Volume	51
Issue number	1
DOIs	https://doi.org/10.1128/JCM.02238-12
Publication status	Published - Jan 2013

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Sangal, V., Holt, K., Yuan, J., Brown, D., Filliol-Toutain, I., Weill, F.-X., Kim, D.-W., Dias da Silveira, W., Pickard, D., Thomson, N., Parkhill, J., & Yu, J. (2013). Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis. Journal of Clinical Microbiology, 51(1), 303-5. https://doi.org/10.1128/JCM.02238-12

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title = "Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis.",

abstract = "The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.",

author = "Vartul Sangal and Kathryn Holt and Jianfeng Yuan and Derek Brown and Ingrid Filliol-Toutain and Fran{\c c}ois-Xavier Weill and Dong-Wook Kim and \{Dias da Silveira\}, Wanderley and Derek Pickard and Nicholas Thomson and Julian Parkhill and Jun Yu",

year = "2013",

month = jan,

doi = "10.1128/JCM.02238-12",

language = "English",

volume = "51",

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Sangal, V, Holt, K, Yuan, J, Brown, D, Filliol-Toutain, I, Weill, F-X, Kim, D-W, Dias da Silveira, W, Pickard, D, Thomson, N, Parkhill, J & Yu, J 2013, 'Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis.', Journal of Clinical Microbiology, vol. 51, no. 1, pp. 303-5. https://doi.org/10.1128/JCM.02238-12

Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis. / Sangal, Vartul; Holt, Kathryn; Yuan, Jianfeng et al.
In: Journal of Clinical Microbiology, Vol. 51, No. 1, 01.2013, p. 303-5.

Research output: Contribution to journal › Article › peer-review

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T1 - Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis.

AU - Sangal, Vartul

AU - Holt, Kathryn

AU - Yuan, Jianfeng

AU - Brown, Derek

AU - Filliol-Toutain, Ingrid

AU - Weill, François-Xavier

AU - Kim, Dong-Wook

AU - Dias da Silveira, Wanderley

AU - Pickard, Derek

AU - Thomson, Nicholas

AU - Parkhill, Julian

AU - Yu, Jun

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N2 - The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.

AB - The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.

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U2 - 10.1128/JCM.02238-12

DO - 10.1128/JCM.02238-12

M3 - Article

SN - 0095-1137

VL - 51

SP - 303

EP - 305

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 1

ER -

Sangal V, Holt K, Yuan J, Brown D, Filliol-Toutain I, Weill FX et al. Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis. Journal of Clinical Microbiology. 2013 Jan;51(1):303-5. doi: 10.1128/JCM.02238-12

Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis.

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