Glucose modulates event-related potential components of recollection and familiarity in healthy adolescents

Michael Smith, Leigh Riby, Sandra Sünram-Lea, Anke van Eekelen, Jonathan Foster

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)
3 Downloads (Pure)

Abstract

Behavioural evidence supports the notion that oral glucose ingestion enhances recognition memory judgements based on recollection, but not familiarity. The present study sought to clarify and extend upon these behavioural findings by investigating the influence of glucose administration on event-related potential (ERP) components that are thought to be differentially mediated by recollection and familiarity processes in healthy adolescents. In a within subjects design, participants performed a recognition memory task, during which time EEG was recorded, subsequent to ingestion of either a) glucose, or b) placebo in a counterbalanced order. Response times during the recognition memory task were observed to be faster for the glucose condition, relative to a placebo control. Further, glucose ingestion was associated with an enhanced left parietal old/new ERP effect (a marker of recollection) and an enhanced mid-frontal old/new ERP effect (known to be mediated by familiarity). These findings a) support the results of previous research that the 'glucose memory facilitation effect' can be extended to healthy adolescents, but b) suggest that glucose enhances both the recollection and familiarity components of recognition memory. The observed ERP profile has important implications for the proposal that glucose specifically targets the hippocampus in modulating cognitive performance.
Original languageEnglish
Pages (from-to)11-20
JournalPsychopharmacology
Volume205
Issue number1
DOIs
Publication statusPublished - 2009

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