Hemodialysis-induced chronodisruption and chronotype distribution in patients with chronic kidney disease

Patrícia Pereira Nunes, Caroline Meneses Resende, Ellen Dayanne Barros Silva, Deryc Cleyner Piones Bastos, Max Luiz Mendes Ramires Filho, Mario André Leocadio-Miguel, Mario Pedrazzoli, Manoel Alves Sobreira-Neto, Tiago Gomes De Andrade, Lívia Leite Góes Gitaí*, Flávio Teles

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Changes in circadian rhythms have been observed in patients with chronic kidney disease (CKD), and evidence suggests that these changes can have a negative impact on health. This study aimed to investigate the existence of hemodialysis-induced chronodisruption, the chronotype distribution,
and their association with sleep quality and quality of life (QoL). This was a cross-sectional study that enrolled 165 patients (mean age: 51.1 ± 12.5 y, 60.6% male) undergoing hemodialysis from three local units. The following instruments were used: the Morning-Eveningness Questionnaire (MEQ); a modified version of the Munich Chronotype Questionnaire (MCQT) to
estimate hemodialysis-induced chronodisruption (HIC); the Kidney Disease QoL Short Form (KDQOL-SF); the Epworth Sleepiness Scale (ESS); the Pittsburgh Sleep Quality Index (PSQI) and the 10–Cognitive Screener (10-CS). HIC was present in 40.6% of CKD patients. Morning chronotype was prevalent in CKD patients (69%) compared to evening-type (17.1%) and significantly different from a paired sample from the general population (p < 0.001). HIC and chronotype were associated with different domains of QoL but not with sleep quality. This study suggests that there is a HIC and that morning chronotype is associated with CKD patients undergoing hemodialysis, with implications for QoL.
Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalChronobiology International
Early online date4 Feb 2024
Publication statusE-pub ahead of print - 4 Feb 2024

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