Hemodynamic effects of high intensity interval training in COPD patients exhibiting exercise-induced dynamic hyperinflation

I. Nasis, E. Kortianou, M. Vasilopoulou, S. Spetsioti, Z. Louvaris, G. Kaltsakas, C. H. Davos, S. Zakynthinos, N. G. Koulouris, I. Vogiatzis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Dynamic hyperinflation (DH) has a significant adverse effect on cardiovascular function during exercise in COPD patients. COPD patients with (n=25) and without (n=11) exercise-induced DH undertook an incremental (IET) and a constant-load exercise test (CLET) sustained at 75% peak work (WRpeak) prior to and following an interval cycling exercise training regime (set at 100% WRpeak with 30-s work/30-s rest intervals) lasting for 12 weeks. Cardiac output (Q) was assessed by cardio-bio-impedance (PhysioFlow, enduro, PF-O7) to determine Q mean response time (QMRT) at onset (QMRTON) and offset (QMRTOFF) of CLET. Post-rehabilitation only those patients exhibiting exercise-induced DH demonstrated significant reductions in QMRTON (from 82.2±4.3 to 61.7±4.2s) and QMRTOFF (from 80.5±3.8 to 57.2±4.9s). These post-rehabilitation adaptations were associated with improvements in inspiratory capacity, thereby suggesting that mitigation of the degree of exercise-induced DH improves central hemodynamic responses in COPD patients.

Original languageEnglish
Pages (from-to)8-16
Number of pages9
JournalRespiratory Physiology and Neurobiology
Volume217
Early online date23 Jun 2015
DOIs
Publication statusPublished - 1 Oct 2015
Externally publishedYes

Fingerprint

Dive into the research topics of 'Hemodynamic effects of high intensity interval training in COPD patients exhibiting exercise-induced dynamic hyperinflation'. Together they form a unique fingerprint.

Cite this