Abstract
Dynamic hyperinflation (DH) has a significant adverse effect on cardiovascular function during exercise in COPD patients. COPD patients with (n=25) and without (n=11) exercise-induced DH undertook an incremental (IET) and a constant-load exercise test (CLET) sustained at 75% peak work (WRpeak) prior to and following an interval cycling exercise training regime (set at 100% WRpeak with 30-s work/30-s rest intervals) lasting for 12 weeks. Cardiac output (Q) was assessed by cardio-bio-impedance (PhysioFlow, enduro, PF-O7) to determine Q mean response time (QMRT) at onset (QMRTON) and offset (QMRTOFF) of CLET. Post-rehabilitation only those patients exhibiting exercise-induced DH demonstrated significant reductions in QMRTON (from 82.2±4.3 to 61.7±4.2s) and QMRTOFF (from 80.5±3.8 to 57.2±4.9s). These post-rehabilitation adaptations were associated with improvements in inspiratory capacity, thereby suggesting that mitigation of the degree of exercise-induced DH improves central hemodynamic responses in COPD patients.
Original language | English |
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Pages (from-to) | 8-16 |
Number of pages | 9 |
Journal | Respiratory Physiology and Neurobiology |
Volume | 217 |
Early online date | 23 Jun 2015 |
DOIs | |
Publication status | Published - 1 Oct 2015 |
Externally published | Yes |
Keywords
- Cardiac output
- COPD
- Pulmonary rehabilitation