TY - JOUR
T1 - Hemodynamic effects of portable non-invasive ventilation in healthy men
AU - Chynkiamis, Nikolaos
AU - Armstrong, Matthew
AU - Manifield, James
AU - Hume, Emily
AU - Reilly, Caroline
AU - Aliverti, Andrea
AU - O'Doherty, Alasdair
AU - Vogiatzis, Ioannis
N1 - Funding information: The study was supported by Northumbria University Newcastle.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - VitaBreath is a portable, non-invasive ventilation device (pNIV) that relieves shortness of breath in COPD by delivering fixed inspiratory and expiratory positive airway pressures (IPAP/EPAP: 18/8 cmH2O). Fixed pressures may cause circulatory compromise. We investigated the circulatory effects of pNIV during normal breathing (NB) and after Eucapnic Voluntary Hyperpnoea trials (EVH) sustained at 80% MVV. In a balanced order sequence, 10 healthy men performed four trials on one visit: 1-min of pNIV (intervention) or 1-min quiet breathing (QB) during NB; and 1-min pNIV (intervention) or 1-min QB during recovery from 3-min EVH. Compared to QB, pNIV application was associated with greater cardiac output (CO: 1.6 ± 1.9 L.min-1; P = 0.03). One minute into recovery from EVH, pNIV caused greater CO (2.2 ± 1.6 L.min-1; P = 0.01) compared to QB. Mean blood pressure was not different with pNIV compared to control. pNIV increased thoracoabdominal volumes and breathing frequency during NB and recovery from EVH. pNIV application does not induce adverse hemodynamic effects in healthy men.
AB - VitaBreath is a portable, non-invasive ventilation device (pNIV) that relieves shortness of breath in COPD by delivering fixed inspiratory and expiratory positive airway pressures (IPAP/EPAP: 18/8 cmH2O). Fixed pressures may cause circulatory compromise. We investigated the circulatory effects of pNIV during normal breathing (NB) and after Eucapnic Voluntary Hyperpnoea trials (EVH) sustained at 80% MVV. In a balanced order sequence, 10 healthy men performed four trials on one visit: 1-min of pNIV (intervention) or 1-min quiet breathing (QB) during NB; and 1-min pNIV (intervention) or 1-min QB during recovery from 3-min EVH. Compared to QB, pNIV application was associated with greater cardiac output (CO: 1.6 ± 1.9 L.min-1; P = 0.03). One minute into recovery from EVH, pNIV caused greater CO (2.2 ± 1.6 L.min-1; P = 0.01) compared to QB. Mean blood pressure was not different with pNIV compared to control. pNIV increased thoracoabdominal volumes and breathing frequency during NB and recovery from EVH. pNIV application does not induce adverse hemodynamic effects in healthy men.
KW - Central haemodynamic responses
KW - Non-invasive ventilation
KW - Operational chest wall volumes
UR - http://www.scopus.com/inward/record.url?scp=85068515204&partnerID=8YFLogxK
U2 - 10.1016/j.resp.2019.06.005
DO - 10.1016/j.resp.2019.06.005
M3 - Article
C2 - 31271841
SN - 1569-9048
VL - 268
SP - 1
EP - 9
JO - Respiratory Physiology & Neurobiology
JF - Respiratory Physiology & Neurobiology
M1 - 103248
ER -