Hemodynamic effects of portable non-invasive ventilation in healthy men

Nikolaos Chynkiamis; Matthew Armstrong; James Manifield; Emily Hume; Caroline Reilly; Andrea Aliverti; Alasdair O'Doherty; Ioannis Vogiatzis

doi:10.1016/j.resp.2019.06.005

Hemodynamic effects of portable non-invasive ventilation in healthy men

Nikolaos Chynkiamis, Matthew Armstrong, James Manifield, Emily Hume, Caroline Reilly, Andrea Aliverti, Alasdair O'Doherty, Ioannis Vogiatzis^*

^*Corresponding author for this work

School of Sport Exercise and Rehabilitation

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

32 Downloads (Pure)

Abstract

VitaBreath is a portable, non-invasive ventilation device (pNIV) that relieves shortness of breath in COPD by delivering fixed inspiratory and expiratory positive airway pressures (IPAP/EPAP: 18/8 cmH2O). Fixed pressures may cause circulatory compromise. We investigated the circulatory effects of pNIV during normal breathing (NB) and after Eucapnic Voluntary Hyperpnoea trials (EVH) sustained at 80% MVV. In a balanced order sequence, 10 healthy men performed four trials on one visit: 1-min of pNIV (intervention) or 1-min quiet breathing (QB) during NB; and 1-min pNIV (intervention) or 1-min QB during recovery from 3-min EVH. Compared to QB, pNIV application was associated with greater cardiac output (CO: 1.6 ± 1.9 L.min-1; P = 0.03). One minute into recovery from EVH, pNIV caused greater CO (2.2 ± 1.6 L.min-1; P = 0.01) compared to QB. Mean blood pressure was not different with pNIV compared to control. pNIV increased thoracoabdominal volumes and breathing frequency during NB and recovery from EVH. pNIV application does not induce adverse hemodynamic effects in healthy men.

Original language	English
Article number	103248
Pages (from-to)	1-9
Number of pages	9
Journal	Respiratory Physiology & Neurobiology
Volume	268
Early online date	1 Jul 2019
DOIs	https://doi.org/10.1016/j.resp.2019.06.005
Publication status	Published - 1 Oct 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Central haemodynamic responses
Non-invasive ventilation
Operational chest wall volumes

Access to Document

10.1016/j.resp.2019.06.005

Chynkiamis et al Resp Physiol Neurobiol_2019Accepted author manuscript, 713 KBLicence: CC BY-NC-ND

Cite this

@article{8fdc27c7ca4b407eafd05b8f2072173b,

title = "Hemodynamic effects of portable non-invasive ventilation in healthy men",

abstract = "VitaBreath is a portable, non-invasive ventilation device (pNIV) that relieves shortness of breath in COPD by delivering fixed inspiratory and expiratory positive airway pressures (IPAP/EPAP: 18/8 cmH2O). Fixed pressures may cause circulatory compromise. We investigated the circulatory effects of pNIV during normal breathing (NB) and after Eucapnic Voluntary Hyperpnoea trials (EVH) sustained at 80\% MVV. In a balanced order sequence, 10 healthy men performed four trials on one visit: 1-min of pNIV (intervention) or 1-min quiet breathing (QB) during NB; and 1-min pNIV (intervention) or 1-min QB during recovery from 3-min EVH. Compared to QB, pNIV application was associated with greater cardiac output (CO: 1.6 ± 1.9 L.min-1; P = 0.03). One minute into recovery from EVH, pNIV caused greater CO (2.2 ± 1.6 L.min-1; P = 0.01) compared to QB. Mean blood pressure was not different with pNIV compared to control. pNIV increased thoracoabdominal volumes and breathing frequency during NB and recovery from EVH. pNIV application does not induce adverse hemodynamic effects in healthy men.",

keywords = "Central haemodynamic responses, Non-invasive ventilation, Operational chest wall volumes",

author = "Nikolaos Chynkiamis and Matthew Armstrong and James Manifield and Emily Hume and Caroline Reilly and Andrea Aliverti and Alasdair O'Doherty and Ioannis Vogiatzis",

note = "Funding information: The study was supported by Northumbria University Newcastle.",

year = "2019",

month = oct,

day = "1",

doi = "10.1016/j.resp.2019.06.005",

language = "English",

volume = "268",

pages = "1--9",

journal = "Respiratory Physiology \& Neurobiology",

issn = "1569-9048",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Hemodynamic effects of portable non-invasive ventilation in healthy men

AU - Chynkiamis, Nikolaos

AU - Armstrong, Matthew

AU - Manifield, James

AU - Hume, Emily

AU - Reilly, Caroline

AU - Aliverti, Andrea

AU - O'Doherty, Alasdair

AU - Vogiatzis, Ioannis

N1 - Funding information: The study was supported by Northumbria University Newcastle.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - VitaBreath is a portable, non-invasive ventilation device (pNIV) that relieves shortness of breath in COPD by delivering fixed inspiratory and expiratory positive airway pressures (IPAP/EPAP: 18/8 cmH2O). Fixed pressures may cause circulatory compromise. We investigated the circulatory effects of pNIV during normal breathing (NB) and after Eucapnic Voluntary Hyperpnoea trials (EVH) sustained at 80% MVV. In a balanced order sequence, 10 healthy men performed four trials on one visit: 1-min of pNIV (intervention) or 1-min quiet breathing (QB) during NB; and 1-min pNIV (intervention) or 1-min QB during recovery from 3-min EVH. Compared to QB, pNIV application was associated with greater cardiac output (CO: 1.6 ± 1.9 L.min-1; P = 0.03). One minute into recovery from EVH, pNIV caused greater CO (2.2 ± 1.6 L.min-1; P = 0.01) compared to QB. Mean blood pressure was not different with pNIV compared to control. pNIV increased thoracoabdominal volumes and breathing frequency during NB and recovery from EVH. pNIV application does not induce adverse hemodynamic effects in healthy men.

AB - VitaBreath is a portable, non-invasive ventilation device (pNIV) that relieves shortness of breath in COPD by delivering fixed inspiratory and expiratory positive airway pressures (IPAP/EPAP: 18/8 cmH2O). Fixed pressures may cause circulatory compromise. We investigated the circulatory effects of pNIV during normal breathing (NB) and after Eucapnic Voluntary Hyperpnoea trials (EVH) sustained at 80% MVV. In a balanced order sequence, 10 healthy men performed four trials on one visit: 1-min of pNIV (intervention) or 1-min quiet breathing (QB) during NB; and 1-min pNIV (intervention) or 1-min QB during recovery from 3-min EVH. Compared to QB, pNIV application was associated with greater cardiac output (CO: 1.6 ± 1.9 L.min-1; P = 0.03). One minute into recovery from EVH, pNIV caused greater CO (2.2 ± 1.6 L.min-1; P = 0.01) compared to QB. Mean blood pressure was not different with pNIV compared to control. pNIV increased thoracoabdominal volumes and breathing frequency during NB and recovery from EVH. pNIV application does not induce adverse hemodynamic effects in healthy men.

KW - Central haemodynamic responses

KW - Non-invasive ventilation

KW - Operational chest wall volumes

UR - https://www.scopus.com/pages/publications/85068515204

U2 - 10.1016/j.resp.2019.06.005

DO - 10.1016/j.resp.2019.06.005

M3 - Article

C2 - 31271841

SN - 1569-9048

VL - 268

SP - 1

EP - 9

JO - Respiratory Physiology & Neurobiology

JF - Respiratory Physiology & Neurobiology

M1 - 103248

ER -

Hemodynamic effects of portable non-invasive ventilation in healthy men

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this