TY - JOUR
T1 - Heritability of sleep architecture based on home polysomnography
AU - Leocadio-Miguel, Mario
AU - Taporoski, Tâmara P.
AU - Beijamini, Felipe
AU - Ruiz, Francieli S.
AU - Pereira, Alexandre C.
AU - Knutson, Kristen L.
AU - von Schantz, Malcolm
PY - 2024/12/29
Y1 - 2024/12/29
N2 - We aimed to establish the heritability of polysomnography measures through the analysis of home polysomnography recordings from 648 participants in the Baependi Heart Study, a rural, family-based, genetically admixed cohort based in the southeast of Brazil. Sleep polysomnography staging variables were computed, and narrow-sense heritability values were derived. The heritability (h2) of polysomnography total sleep time was 0.18 ± 0.08 (p = 0.007). Including age and sex did not change the heritability estimates of the model. Wake after sleep onset did not show significant heritability (h2 = 0.02 ± 0.07, p = 0.39). The unadjusted model for N1 resulted in a heritability estimate of 0.22 ± 0.10 (p < 0.003), and of 0.26 ± 0.10 (p = 0.003) in the adjusted model. Time spent in N2 had an unadjusted heritability of 0.18 ± 0.09 (p = 0.01) and adjusted h2 of 0.22 ± 0.10 (p = 0.007). The heritability of the total time spent in N3 was 0.35 ± 0.09 (p < 0.001) in the unadjusted and 0.38 ± 0.09 (p < 0.001) when sex, age and age*age were considered in the model. By contrast, no variance in the total time spent in rapid eye movement could be significantly attributed to genetic variance. In terms of the heritability of the apnea–hypopnea index, 17% of its variance could be attributed to genetic factors (0.17 ± 0.08, p = 0.02). This is the first report of heritability of electroencephalographic-derived sleep parameters from a larger population sample, and the first one performed in a population with a majority above 25 years of age. Our findings indicate the potential feasibility of future genome-wide association studies of non-rapid eye movement sleep stages in pooled population samples.
AB - We aimed to establish the heritability of polysomnography measures through the analysis of home polysomnography recordings from 648 participants in the Baependi Heart Study, a rural, family-based, genetically admixed cohort based in the southeast of Brazil. Sleep polysomnography staging variables were computed, and narrow-sense heritability values were derived. The heritability (h2) of polysomnography total sleep time was 0.18 ± 0.08 (p = 0.007). Including age and sex did not change the heritability estimates of the model. Wake after sleep onset did not show significant heritability (h2 = 0.02 ± 0.07, p = 0.39). The unadjusted model for N1 resulted in a heritability estimate of 0.22 ± 0.10 (p < 0.003), and of 0.26 ± 0.10 (p = 0.003) in the adjusted model. Time spent in N2 had an unadjusted heritability of 0.18 ± 0.09 (p = 0.01) and adjusted h2 of 0.22 ± 0.10 (p = 0.007). The heritability of the total time spent in N3 was 0.35 ± 0.09 (p < 0.001) in the unadjusted and 0.38 ± 0.09 (p < 0.001) when sex, age and age*age were considered in the model. By contrast, no variance in the total time spent in rapid eye movement could be significantly attributed to genetic variance. In terms of the heritability of the apnea–hypopnea index, 17% of its variance could be attributed to genetic factors (0.17 ± 0.08, p = 0.02). This is the first report of heritability of electroencephalographic-derived sleep parameters from a larger population sample, and the first one performed in a population with a majority above 25 years of age. Our findings indicate the potential feasibility of future genome-wide association studies of non-rapid eye movement sleep stages in pooled population samples.
KW - electroencephalogram
KW - genetic admixture
KW - genetic variance
KW - paradoxical sleep
KW - slow-wave sleep
UR - http://www.scopus.com/inward/record.url?scp=85213358436&partnerID=8YFLogxK
U2 - 10.1111/jsr.14448
DO - 10.1111/jsr.14448
M3 - Article
SN - 0962-1105
JO - Journal of Sleep Research
JF - Journal of Sleep Research
M1 - e14448
ER -