TY - JOUR
T1 - High force unimanual handgrip contractions increase ipsilateral sensorimotor activation and functional connectivity
AU - Andrushko, Justin W.
AU - Gould, Layla A.
AU - Renshaw, Doug W.
AU - Ekstrand, Chelsea
AU - Hortobágyi, Tibor
AU - Borowsky, Ron
AU - Farthing, Jonathan P.
N1 - Funding information: Research funded by Natural Sciences and Engineering Research Council of Canada (2016-0529), NSERC (183968-2013-22).
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Imaging and brain stimulation studies seem to correct the classical understanding of how brain networks, rather than contralateral focal areas, control the generation of unimanual voluntary force. However, the scaling and hemispheric-specificity of network activation remain less understood. Using fMRI, we examined the effects of parametrically increasing right-handgrip force on activation and functional connectivity among the sensorimotor network bilaterally with 25%, 50%, and 75% maximal voluntary contractions (MVC). High force (75% MVC) unimanual handgrip contractions resulted in greater ipsilateral motor activation and functional connectivity with the contralateral hemisphere compared to a low force 25% MVC condition. The ipsilateral motor cortex activation and network strength correlated with relative handgrip force (% MVC). Increases in unimanual handgrip force resulted in greater ipsilateral sensorimotor activation and greater functional connectivity between hemispheres within the sensorimotor network.
AB - Imaging and brain stimulation studies seem to correct the classical understanding of how brain networks, rather than contralateral focal areas, control the generation of unimanual voluntary force. However, the scaling and hemispheric-specificity of network activation remain less understood. Using fMRI, we examined the effects of parametrically increasing right-handgrip force on activation and functional connectivity among the sensorimotor network bilaterally with 25%, 50%, and 75% maximal voluntary contractions (MVC). High force (75% MVC) unimanual handgrip contractions resulted in greater ipsilateral motor activation and functional connectivity with the contralateral hemisphere compared to a low force 25% MVC condition. The ipsilateral motor cortex activation and network strength correlated with relative handgrip force (% MVC). Increases in unimanual handgrip force resulted in greater ipsilateral sensorimotor activation and greater functional connectivity between hemispheres within the sensorimotor network.
KW - fMRI
KW - functional connectivity
KW - ipsilateral activation
KW - sensorimotor network
KW - unimanual handgrip
UR - https://www.mendeley.com/catalogue/e0fba607-7ab8-3b29-a463-3d96475c816e/
U2 - 10.1016/j.neuroscience.2020.10.031
DO - 10.1016/j.neuroscience.2020.10.031
M3 - Article
C2 - 33197497
SN - 0306-4522
VL - 452
SP - 111
EP - 125
JO - Neuroscience
JF - Neuroscience
ER -