Highly Sensitive Label-Free Biosensor Based on Microbottle Cavity-Gold Nanocoated Layer for Facile Detection of COVID-19 RNA

Houchang Li; Jinhui Yuan; Yuwei Qu; Binbin Yan; Kuiru Wang; Qiang Wu; Bin Liu

doi:10.1109/csndsp60683.2024.10636390

Highly Sensitive Label-Free Biosensor Based on Microbottle Cavity-Gold Nanocoated Layer for Facile Detection of COVID-19 RNA

Houchang Li, Jinhui Yuan, Yuwei Qu, Binbin Yan, Kuiru Wang, Qiang Wu, Bin Liu

Mathematics, Physics and Electrical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

To improve the sensitivity of the whispering-gallery mode microbottle cavity to the low-concentration solution, a nanoparticle gold film-modified microbottle cavity sensor is proposed and demonstrated by measuring the low concentration measurement of RNA virus (COVID-19) molecules. The results show that the refractive index sensitivity of the micro-bottle cavity can be effectively improved by a nano-gold film, which can reach 261 nm/RIU in the refractive index range of 1.3320 to 1.3332. In the 10 pg/ml concentration range to 100 ng/ml COVID-19 RNA, the sensor output signal has a linear relationship with the concentration, and the detection limit can reach 10 pg/ml. The sensor has high sensitivity and strong stability and has broad application prospects in the field of biosensing.

Original language	English
Title of host publication	2024 14th International Symposium on Communication Systems, Networks and Digital Signal Processing (CSNDSP)
Place of Publication	Piscataway, USA
Publisher	IEEE
Pages	342-345
Number of pages	4
ISBN (Electronic)	9798350348743
ISBN (Print)	9798350348750
DOIs	https://doi.org/10.1109/csndsp60683.2024.10636390
Publication status	Published - 19 Jul 2024
Event	2024 14th International Symposium on Communication Systems, Networks and Digital Signal Processing (CSNDSP) - Rome, Italy Duration: 17 Jul 2024 → 19 Jul 2024 Conference number: 14

Conference

Conference	2024 14th International Symposium on Communication Systems, Networks and Digital Signal Processing (CSNDSP)
Abbreviated title	CSNDSP
Country/Territory	Italy
City	Rome
Period	17/07/24 → 19/07/24

Keywords

fiber optic biosensing
microbottle resonator
gold nanoparticles
COVID-19 RNA

Access to Document

10.1109/csndsp60683.2024.10636390

Cite this

Li, H., Yuan, J., Qu, Y., Yan, B., Wang, K., Wu, Q., & Liu, B. (2024). Highly Sensitive Label-Free Biosensor Based on Microbottle Cavity-Gold Nanocoated Layer for Facile Detection of COVID-19 RNA. In 2024 14th International Symposium on Communication Systems, Networks and Digital Signal Processing (CSNDSP) (pp. 342-345). IEEE. https://doi.org/10.1109/csndsp60683.2024.10636390

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title = "Highly Sensitive Label-Free Biosensor Based on Microbottle Cavity-Gold Nanocoated Layer for Facile Detection of COVID-19 RNA",

abstract = "To improve the sensitivity of the whispering-gallery mode microbottle cavity to the low-concentration solution, a nanoparticle gold film-modified microbottle cavity sensor is proposed and demonstrated by measuring the low concentration measurement of RNA virus (COVID-19) molecules. The results show that the refractive index sensitivity of the micro-bottle cavity can be effectively improved by a nano-gold film, which can reach 261 nm/RIU in the refractive index range of 1.3320 to 1.3332. In the 10 pg/ml concentration range to 100 ng/ml COVID-19 RNA, the sensor output signal has a linear relationship with the concentration, and the detection limit can reach 10 pg/ml. The sensor has high sensitivity and strong stability and has broad application prospects in the field of biosensing.",

keywords = "fiber optic biosensing, microbottle resonator, gold nanoparticles, COVID-19 RNA",

author = "Houchang Li and Jinhui Yuan and Yuwei Qu and Binbin Yan and Kuiru Wang and Qiang Wu and Bin Liu",

year = "2024",

month = jul,

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booktitle = "2024 14th International Symposium on Communication Systems, Networks and Digital Signal Processing (CSNDSP)",

publisher = "IEEE",

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note = "2024 14th International Symposium on Communication Systems, Networks and Digital Signal Processing (CSNDSP), CSNDSP ; Conference date: 17-07-2024 Through 19-07-2024",

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Li, H, Yuan, J, Qu, Y, Yan, B, Wang, K, Wu, Q & Liu, B 2024, Highly Sensitive Label-Free Biosensor Based on Microbottle Cavity-Gold Nanocoated Layer for Facile Detection of COVID-19 RNA. in 2024 14th International Symposium on Communication Systems, Networks and Digital Signal Processing (CSNDSP). IEEE, Piscataway, USA, pp. 342-345, 2024 14th International Symposium on Communication Systems, Networks and Digital Signal Processing (CSNDSP), Rome, Italy, 17/07/24. https://doi.org/10.1109/csndsp60683.2024.10636390

Highly Sensitive Label-Free Biosensor Based on Microbottle Cavity-Gold Nanocoated Layer for Facile Detection of COVID-19 RNA. / Li, Houchang; Yuan, Jinhui; Qu, Yuwei et al.
2024 14th International Symposium on Communication Systems, Networks and Digital Signal Processing (CSNDSP). Piscataway, USA: IEEE, 2024. p. 342-345.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Highly Sensitive Label-Free Biosensor Based on Microbottle Cavity-Gold Nanocoated Layer for Facile Detection of COVID-19 RNA

AU - Li, Houchang

AU - Yuan, Jinhui

AU - Qu, Yuwei

AU - Yan, Binbin

AU - Wang, Kuiru

AU - Wu, Qiang

AU - Liu, Bin

N1 - Conference code: 14

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N2 - To improve the sensitivity of the whispering-gallery mode microbottle cavity to the low-concentration solution, a nanoparticle gold film-modified microbottle cavity sensor is proposed and demonstrated by measuring the low concentration measurement of RNA virus (COVID-19) molecules. The results show that the refractive index sensitivity of the micro-bottle cavity can be effectively improved by a nano-gold film, which can reach 261 nm/RIU in the refractive index range of 1.3320 to 1.3332. In the 10 pg/ml concentration range to 100 ng/ml COVID-19 RNA, the sensor output signal has a linear relationship with the concentration, and the detection limit can reach 10 pg/ml. The sensor has high sensitivity and strong stability and has broad application prospects in the field of biosensing.

AB - To improve the sensitivity of the whispering-gallery mode microbottle cavity to the low-concentration solution, a nanoparticle gold film-modified microbottle cavity sensor is proposed and demonstrated by measuring the low concentration measurement of RNA virus (COVID-19) molecules. The results show that the refractive index sensitivity of the micro-bottle cavity can be effectively improved by a nano-gold film, which can reach 261 nm/RIU in the refractive index range of 1.3320 to 1.3332. In the 10 pg/ml concentration range to 100 ng/ml COVID-19 RNA, the sensor output signal has a linear relationship with the concentration, and the detection limit can reach 10 pg/ml. The sensor has high sensitivity and strong stability and has broad application prospects in the field of biosensing.

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BT - 2024 14th International Symposium on Communication Systems, Networks and Digital Signal Processing (CSNDSP)

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