How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase?

Tatyana Karabencheva-Christova, Christian Lee, Gary Black, Rossen Donev, Christo Christov

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)
4 Downloads (Pure)

Abstract

Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently occurring and clinically important activation mutants we revealed important conformational effects on key interactions responsible for the activation of the enzyme.
Original languageEnglish
Pages (from-to)1490-1495
JournalMolecular BioSystems
Volume10
DOIs
Publication statusPublished - 1 Jun 2014

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