TY - JOUR
T1 - Hydrogel Bioadhesives with Extreme Acid-Tolerance for Gastric Perforation Repairing
AU - Chen, Xingmei
AU - Zhang, Jun
AU - Chen, Guangda
AU - Xue, Yu
AU - Zhang, Jiajun
AU - Liang, Xiangyu
AU - Lei, Iek Man
AU - Lin, Jingsen
AU - Xu, Ben Bin
AU - Liu, Ji
N1 - Funding information: J.L. acknowledges the research startup grant from Shenzhen municipal government (Y01336223) and the research startup grant from SUSTech (Y01336123) ), and the financial support by MechERE Centers at MIT and SUSTech (Y01346002). This work was also supported in part by the Science, Technology and Innovation Commission of Shenzhen Municipality (ZDSYS20200811143601004), Basic and Applied Basic Research Foundation of Guangdong Province (2020A1515110288) and the Basic Research Program of Shenzhen (JCYJ20210324105211032).
PY - 2022/7/18
Y1 - 2022/7/18
N2 - Hydrogel bioadhesives have emerged as one of the most promising alternatives to sutures and staples for wound sealing and repairing, owing to their unique advantages in biocompatibility, mechanical compliance and minimally invasive manipulation. However, only a few hydrogel bioadhesives have been successfully used for gastric perforation repairing, due to their undesirable swelling when in direct contacting with extremely acidic gastric fluids, thereby accompanying with a graduallydeteriorated adhesion performance. Herein, we develop an acid-tolerant hydrogels (ATGels) bioadhesive, which integrates two distinct components, an acid-tolerant hydrogel substrate and an adhesive polymer brush layer. The ATGels bioadhesive could form instant, atraumatic, fluid-tight and sutureless sealing of gastric perforation, and enable robust biointerfaces in direct contact with gastric fluids, addressing the key limitations with sutures and commercially-available tissue adhesives. Moreover, in vivo investigation on gastric perforation of rat model validates the proposed acid-tolerant bioadhesion, and identifies the mechanisms for accelerated gastric perforation repairing through alleviated inflammation, which suppressed fibrosis and enhanced angiogenesis.
AB - Hydrogel bioadhesives have emerged as one of the most promising alternatives to sutures and staples for wound sealing and repairing, owing to their unique advantages in biocompatibility, mechanical compliance and minimally invasive manipulation. However, only a few hydrogel bioadhesives have been successfully used for gastric perforation repairing, due to their undesirable swelling when in direct contacting with extremely acidic gastric fluids, thereby accompanying with a graduallydeteriorated adhesion performance. Herein, we develop an acid-tolerant hydrogels (ATGels) bioadhesive, which integrates two distinct components, an acid-tolerant hydrogel substrate and an adhesive polymer brush layer. The ATGels bioadhesive could form instant, atraumatic, fluid-tight and sutureless sealing of gastric perforation, and enable robust biointerfaces in direct contact with gastric fluids, addressing the key limitations with sutures and commercially-available tissue adhesives. Moreover, in vivo investigation on gastric perforation of rat model validates the proposed acid-tolerant bioadhesion, and identifies the mechanisms for accelerated gastric perforation repairing through alleviated inflammation, which suppressed fibrosis and enhanced angiogenesis.
KW - biointerface
KW - gastric perforation
KW - hydrogel bioadhesives
KW - robustness
KW - swelling resistance
KW - gastric perforation
KW - hydrogel bioadhesives
UR - http://www.scopus.com/inward/record.url?scp=85127647675&partnerID=8YFLogxK
U2 - 10.1002/adfm.202202285
DO - 10.1002/adfm.202202285
M3 - Article
SN - 1616-301X
VL - 32
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 29
M1 - 2202285
ER -