Identification of B2 Bradykinin Binding Sites on Cultured Cortical Astrocytes

A. J. Cholewinski, G. Stevens, Alison McDermott, G. P. Wilkin

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

Bradykinin was found to bind to specific high-affinity sites in cultured cortical astrocytes from rat brain, and this binding appeared to be specific for the B2 bradykinin receptor subtype. Nonlinear regression analysis of saturation experiments using a computer programme revealed a single KD of 16.6 ± 2.6 nM and a Bmax of 352.2 ±30.7 fmol/mg of protein. These results indicate that astrocytes possess bradykinin receptors and that these are predominantly of the B2 subtype.
Original languageEnglish
Pages (from-to)1456-1458
JournalJournal of Neurochemistry
Volume57
Issue number4
DOIs
Publication statusPublished - Oct 1991

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