IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4

Iain MacArthur; Paul B. Mann; Eric T. Harvill; Andrew Preston

doi:10.1177/0968051907082609

IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4

Iain MacArthur, Paul B. Mann, Eric T. Harvill, Andrew Preston

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

Original language	English
Pages (from-to)	243-7
Number of pages	5
Journal	Journal of Endotoxin Research
Volume	13
Issue number	4
DOIs	https://doi.org/10.1177/0968051907082609
Publication status	Published - 1 Aug 2007
Externally published	Yes

Keywords

Bordetella/classification
Bordetella Infections/physiopathology
Humans
Lipid A/chemistry
Models, Molecular
Species Specificity
Toll-Like Receptor 4/physiology

Access to Document

10.1177/0968051907082609

Cite this

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title = "IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4",

abstract = "The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.",

keywords = "Bordetella/classification, Bordetella Infections/physiopathology, Humans, Lipid A/chemistry, Models, Molecular, Species Specificity, Toll-Like Receptor 4/physiology",

author = "Iain MacArthur and Mann, {Paul B.} and Harvill, {Eric T.} and Andrew Preston",

year = "2007",

month = aug,

day = "1",

doi = "10.1177/0968051907082609",

language = "English",

volume = "13",

pages = "243--7",

journal = "Journal of Endotoxin Research",

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T2 - Bordetella evolution: lipid A and Toll-like receptor 4

AU - MacArthur, Iain

AU - Mann, Paul B.

AU - Harvill, Eric T.

AU - Preston, Andrew

PY - 2007/8/1

Y1 - 2007/8/1

N2 - The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

AB - The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

KW - Bordetella/classification

KW - Bordetella Infections/physiopathology

KW - Humans

KW - Lipid A/chemistry

KW - Models, Molecular

KW - Species Specificity

KW - Toll-Like Receptor 4/physiology

U2 - 10.1177/0968051907082609

DO - 10.1177/0968051907082609

M3 - Article

C2 - 17956943

SN - 0968-0519

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SP - 243

EP - 247

JO - Journal of Endotoxin Research

JF - Journal of Endotoxin Research

IS - 4

ER -