IEIIS Meeting minireview: Bordetella evolution: lipid A and Toll-like receptor 4

Iain MacArthur, Paul B. Mann, Eric T. Harvill, Andrew Preston

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


The evolution of Bordetella pertussis and Bordetella parapertussis from Bordetella bronchiseptica involved changes in host range and pathogenicity. Recent data suggest that the human-adapted Bordetella modified their interaction with host immune systems to effect these changes and that decreased stimulation of Toll-like receptor 4 (TLR4) by lipid A is central to this. We discuss Bordetella lipid A structure and genetics within the context of evolution and host immunity.

Original languageEnglish
Pages (from-to)243-7
Number of pages5
JournalJournal of Endotoxin Research
Issue number4
Publication statusPublished - 1 Aug 2007
Externally publishedYes

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