TY - JOUR
T1 - Impact of hypertension on arterial stiffness and cardiac autonomic modulation in patients with peripheral artery disease: a cross-sectional study
AU - Farah, Breno Quintella
AU - Cucato, Gabriel Grizzo
AU - Andrade-Lima, Aluísio
AU - Soares, Antonio Henrique Germano
AU - Wolosker, Nelson
AU - Ritti-Dias, Raphael Mendes
AU - Correia, Marilia de Almeida
N1 - Funding information:
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq number 409707/2016-3), and a research productivity fellowship (PQ-1D) granted by CNPq.
PY - 2021/11/25
Y1 - 2021/11/25
N2 - To examine the impact of hypertension on cardiovascular health in patients with symptomatic peripheral artery disease and to identify factors associated with uncontrolled hypertension. A cross-sectional study including 251 patients with symptomatic peripheral artery disease (63.9% males, mean age 67±10 years). Following hypertension diagnosis, blood pressure was measured to determine control of hypertension. Arterial stiffness (carotid-femoral pulse wave velocity) and cardiac autonomic modulation (sympathovagal balance) were assessed. Hypertension was associated with higher carotid-femoral pulse wave velocity, regardless of sex, age, ankle-brachial index, body mass index, walking capacity, heart rate, or comorbidities (ß=2.59±0.76m/s, b=0.318, p=0.003). Patients with systolic blood pressure ≥120mmHg had higher carotid-femoral pulse wave velocity values than normotensive individuals, and hypertensive patients with systolic blood pressure of ≤119mmHg (normotensive: 7.6±2.4m/s=≤119mmHg: 8.1±2.2m/s 120-129mmHg:9.8±2.6m/s=≥130mmHg: 9.9±2.9m/s, p0.05). Hypertensive patients with symptomatic peripheral artery disease have increased arterial stiffness. Arterial stiffness is even greater in patients with uncontrolled high blood pressure.
AB - To examine the impact of hypertension on cardiovascular health in patients with symptomatic peripheral artery disease and to identify factors associated with uncontrolled hypertension. A cross-sectional study including 251 patients with symptomatic peripheral artery disease (63.9% males, mean age 67±10 years). Following hypertension diagnosis, blood pressure was measured to determine control of hypertension. Arterial stiffness (carotid-femoral pulse wave velocity) and cardiac autonomic modulation (sympathovagal balance) were assessed. Hypertension was associated with higher carotid-femoral pulse wave velocity, regardless of sex, age, ankle-brachial index, body mass index, walking capacity, heart rate, or comorbidities (ß=2.59±0.76m/s, b=0.318, p=0.003). Patients with systolic blood pressure ≥120mmHg had higher carotid-femoral pulse wave velocity values than normotensive individuals, and hypertensive patients with systolic blood pressure of ≤119mmHg (normotensive: 7.6±2.4m/s=≤119mmHg: 8.1±2.2m/s 120-129mmHg:9.8±2.6m/s=≥130mmHg: 9.9±2.9m/s, p0.05). Hypertensive patients with symptomatic peripheral artery disease have increased arterial stiffness. Arterial stiffness is even greater in patients with uncontrolled high blood pressure.
KW - Cross-Sectional Studies
KW - Hypertension - complications
KW - Humans
KW - Vascular Stiffness
KW - Aged
KW - Blood Pressure
KW - Male
KW - Peripheral Arterial Disease - complications
KW - Pulse Wave Analysis
KW - Middle Aged
KW - Female
U2 - 10.31744/einstein_journal/2021AO6100
DO - 10.31744/einstein_journal/2021AO6100
M3 - Article
C2 - 34909974
SN - 1679-4508
VL - 19
JO - Einstein (Sao Paulo, Brazil)
JF - Einstein (Sao Paulo, Brazil)
M1 - eA06100
ER -
