Introduction: Beneficial effects of wild green oat extract (WGOE) on cognitive function have previously been demonstrated in both animal and human trials. In addition, acute modulatory effects of WGOE on cerebro-electrical activity have been demonstrated, and chronic administration of 1500 mg/d WGOE has been shown to improve peripheral and cerebral vasodilation. Objectives: The current study aimed to investigate the effects of separate single doses of WGOE on the performance of a wide range of computerised cognitive tasks assessing aspects of attention, memory and executive function. Method / Design: Forty-two healthy adults aged 40-65 years who self-reported memory decline took part. The study employed a double-blind, placebo controlled, cross-over design with cognitive performance and mood being assessed at baseline and 1, 2.5, 4 and 6 hours after the consumption of placebo and two separate doses of WGOE (800 mg, 1600 mg). Each treatment was taken on two occasions (i.e. a total of 6 assessments). The assessments were separated by a 7 day wash-out period. Results: The data indicate that the ingestion of single doses of 800 mg of WGOE was associated with a number of significant benefits to cognitive function. Most notably, 800 mg led to a significant improvement on a global ‘Speed of Performance’ measure. This dose was also associated with some evidence of improved performance on individual tasks spanning several cognitive domains (e.g. executive function, working memory, episodic memory performance). The pattern for the 1600 mg dose was less pronounced with both improvements and decrements being observed across a small number of tasks. Conclusions: The lower (800 mg) of two doses of WGOE administered to older adults who self-reported age-associated cognitive decline resulted in broad improvements to cognitive function. The effects of the higher dose (1600 mg) were equivocal.
|Publication status||Published - Oct 2015|
|Event||12th European Nutrition Conference (FENS) - Berlin, Germany|
Duration: 1 Oct 2015 → …
|Conference||12th European Nutrition Conference (FENS)|
|Period||1/10/15 → …|