TY - JOUR
T1 - Increased incidence of gestational hypertension and preeclampsia after assisted reproductive technology treatment
AU - Wang, Yueping A.
AU - Chughtai, Abrar A.
AU - Farquhar, Cynthia M.
AU - Pollock, Wendy
AU - Lui, Kei
AU - Sullivan, Elizabeth A.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Objective To determine the association between assisted reproductive technology (ART) treatment and the rate of combined gestational hypertension (GH), preeclampsia (PE). Design Retrospective population study. Setting Not applicable. Patient(s) A total of 596,520 mothers (3.6% ART mothers) who gave birth between 2007 and 2011. Intervention(s) Not applicable. Main Outcome Measure(s) Comparison of the rate of GH/PE for ART and non-ART mothers, with odds ratio (OR), adjusted odds ratio (AOR), and 95% confidence interval (CI) used to assess the association between ART and GH/PE. Result(s) The overall rate of GH/PE was 4.3%, with 6.4% for ART mothers and 4.3% for non-ART mothers. The rate of GH/PE was higher for mothers of twins than singletons (12.4% vs. 5.7% for ART mothers; 8.6% vs. 4.2% for non-ART mothers). The ART mothers had a 17% increased odds of GH/PE compared with the non-ART mothers (AOR 1.17; 95% CI, 1.10-1.24). After stratification by plurality, the difference in GH/PE rates between ART and non-ART mothers was not statistically significant, with AOR 1.05 (95% CI, 0.98-1.12) for mothers of singletons and AOR 1.10 (95% CI, 0.94-1.30) for mothers of twins. Conclusion(s) The changes in AOR after stratification indicated that multiple pregnancies after ART are the single most likely explanation for the increased rate of GH/PE among ART mothers. The lower rate of GH/PE among mothers of singletons compared with mothers of twins suggests that a policy to minimize multiple pregnancies after ART may reduce the excess risk of GH/PE due to ART treatment.
AB - Objective To determine the association between assisted reproductive technology (ART) treatment and the rate of combined gestational hypertension (GH), preeclampsia (PE). Design Retrospective population study. Setting Not applicable. Patient(s) A total of 596,520 mothers (3.6% ART mothers) who gave birth between 2007 and 2011. Intervention(s) Not applicable. Main Outcome Measure(s) Comparison of the rate of GH/PE for ART and non-ART mothers, with odds ratio (OR), adjusted odds ratio (AOR), and 95% confidence interval (CI) used to assess the association between ART and GH/PE. Result(s) The overall rate of GH/PE was 4.3%, with 6.4% for ART mothers and 4.3% for non-ART mothers. The rate of GH/PE was higher for mothers of twins than singletons (12.4% vs. 5.7% for ART mothers; 8.6% vs. 4.2% for non-ART mothers). The ART mothers had a 17% increased odds of GH/PE compared with the non-ART mothers (AOR 1.17; 95% CI, 1.10-1.24). After stratification by plurality, the difference in GH/PE rates between ART and non-ART mothers was not statistically significant, with AOR 1.05 (95% CI, 0.98-1.12) for mothers of singletons and AOR 1.10 (95% CI, 0.94-1.30) for mothers of twins. Conclusion(s) The changes in AOR after stratification indicated that multiple pregnancies after ART are the single most likely explanation for the increased rate of GH/PE among ART mothers. The lower rate of GH/PE among mothers of singletons compared with mothers of twins suggests that a policy to minimize multiple pregnancies after ART may reduce the excess risk of GH/PE due to ART treatment.
KW - Assisted reproductive technology
KW - gestational hypertension
KW - preeclampsia
UR - http://www.scopus.com/inward/record.url?scp=84957831066&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2015.12.024
DO - 10.1016/j.fertnstert.2015.12.024
M3 - Article
C2 - 26780118
AN - SCOPUS:84957831066
VL - 105
SP - 920-926.e2
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 4
ER -