Inflammasome lights up in systemic sclerosis

John Henderson; Steven O'Reilly

doi:10.1186/s13075-017-1420-z

Inflammasome lights up in systemic sclerosis

John Henderson, Steven O'Reilly^*

^*Corresponding author for this work

Applied Sciences Department

Research output: Contribution to journal › Editorial › peer-review

10 Citations (Scopus)

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Abstract

Systemic sclerosis (SSc) is a pro-fibrotic condition with a poorly understood aetiology. Evidence presented by Artlett et al. in this issue suggests that the microRNA miR-155 is key, with its involvement dependent on the NLRP3 inflammasome. This links epigenetic events with inflammasome signalling in SSc and opens the door to new therapeutic strategies for the treatment of SSc.

Original language	English
Article number	205
Number of pages	2
Journal	Arthritis Research & Therapy
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s13075-017-1420-z
Publication status	Published - 18 Sept 2017

Keywords

Sclerosis
Fibrosis
Inflammasome
microRNA
Epigenetics
Interleukin-1
Caspase-1
MCC950

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title = "Inflammasome lights up in systemic sclerosis",

abstract = "Systemic sclerosis (SSc) is a pro-fibrotic condition with a poorly understood aetiology. Evidence presented by Artlett et al. in this issue suggests that the microRNA miR-155 is key, with its involvement dependent on the NLRP3 inflammasome. This links epigenetic events with inflammasome signalling in SSc and opens the door to new therapeutic strategies for the treatment of SSc.",

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AU - O'Reilly, Steven

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AB - Systemic sclerosis (SSc) is a pro-fibrotic condition with a poorly understood aetiology. Evidence presented by Artlett et al. in this issue suggests that the microRNA miR-155 is key, with its involvement dependent on the NLRP3 inflammasome. This links epigenetic events with inflammasome signalling in SSc and opens the door to new therapeutic strategies for the treatment of SSc.

KW - Sclerosis

KW - Fibrosis

KW - Inflammasome

KW - microRNA

KW - Epigenetics

KW - Interleukin-1

KW - Caspase-1

KW - MCC950

U2 - 10.1186/s13075-017-1420-z

DO - 10.1186/s13075-017-1420-z

M3 - Editorial

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VL - 19

JO - Arthritis Research & Therapy

JF - Arthritis Research & Therapy

IS - 1

M1 - 205

ER -

Inflammasome lights up in systemic sclerosis

Abstract

Keywords

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