Insights into the Plasmodium falciparum schizont phospho-proteome

Edwin Lasonder; Moritz Treeck; Mahmood Alam; Andrew B. Tobin

doi:10.1016/j.micinf.2012.04.008

Insights into the Plasmodium falciparum schizont phospho-proteome

Edwin Lasonder^*, Moritz Treeck, Mahmood Alam, Andrew B. Tobin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

It is becoming clear that, as is the case with many human diseases, targeting protein phosphorylation in strategies aimed at developing the next generation of anti-malarials is likely to bear considerable fruit. A major barrier to this development, however, is the paucity of information regarding the role of protein phosphorylation in malaria. A major step has recently been taken in this area with the publication of the first analyses of the phospho-proteome of the most virulent species of human malaria Plasmodium falciparum. Here, we discuss these studies.

Original language	English
Pages (from-to)	811-819
Number of pages	9
Journal	Microbes and Infection
Volume	14
Issue number	10
Early online date	5 May 2012
DOIs	https://doi.org/10.1016/j.micinf.2012.04.008
Publication status	Published - 1 Aug 2012
Externally published	Yes

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10.1016/j.micinf.2012.04.008

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title = "Insights into the Plasmodium falciparum schizont phospho-proteome",

abstract = "It is becoming clear that, as is the case with many human diseases, targeting protein phosphorylation in strategies aimed at developing the next generation of anti-malarials is likely to bear considerable fruit. A major barrier to this development, however, is the paucity of information regarding the role of protein phosphorylation in malaria. A major step has recently been taken in this area with the publication of the first analyses of the phospho-proteome of the most virulent species of human malaria Plasmodium falciparum. Here, we discuss these studies.",

keywords = "Phospho-proteome, Plasmodium falciparum, Protein kinase, Schizont, Signalling, Toxoplasma gondii",

author = "Edwin Lasonder and Moritz Treeck and Mahmood Alam and Tobin, {Andrew B.}",

note = "Funding Information: The work carried for the Lasonder study was supported by MALSIG and EVIMALAR. MT was supported in parts by the German Research Foundation , the American Heart Foundation and the NIH ( AI09763301 ). The work by MA and ABT is supported by the Wellcome Trust ( 090313 ). We thank Christian Doerig, John Sanders and Josh Elias for critical reading and input and Christina Ludwig and Ruedi Aebersold for sharing unpublished results. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",

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AU - Lasonder, Edwin

AU - Treeck, Moritz

AU - Alam, Mahmood

AU - Tobin, Andrew B.

N1 - Funding Information: The work carried for the Lasonder study was supported by MALSIG and EVIMALAR. MT was supported in parts by the German Research Foundation , the American Heart Foundation and the NIH ( AI09763301 ). The work by MA and ABT is supported by the Wellcome Trust ( 090313 ). We thank Christian Doerig, John Sanders and Josh Elias for critical reading and input and Christina Ludwig and Ruedi Aebersold for sharing unpublished results. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.

PY - 2012/8/1

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N2 - It is becoming clear that, as is the case with many human diseases, targeting protein phosphorylation in strategies aimed at developing the next generation of anti-malarials is likely to bear considerable fruit. A major barrier to this development, however, is the paucity of information regarding the role of protein phosphorylation in malaria. A major step has recently been taken in this area with the publication of the first analyses of the phospho-proteome of the most virulent species of human malaria Plasmodium falciparum. Here, we discuss these studies.

AB - It is becoming clear that, as is the case with many human diseases, targeting protein phosphorylation in strategies aimed at developing the next generation of anti-malarials is likely to bear considerable fruit. A major barrier to this development, however, is the paucity of information regarding the role of protein phosphorylation in malaria. A major step has recently been taken in this area with the publication of the first analyses of the phospho-proteome of the most virulent species of human malaria Plasmodium falciparum. Here, we discuss these studies.

KW - Phospho-proteome

KW - Plasmodium falciparum

KW - Protein kinase

KW - Schizont

KW - Signalling

KW - Toxoplasma gondii

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JO - Microbes and Infection

JF - Microbes and Infection

SN - 1286-4579

IS - 10

ER -

Insights into the Plasmodium falciparum schizont phospho-proteome

Abstract

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