Insights into the Plasmodium falciparum schizont phospho-proteome

Edwin Lasonder; Moritz Treeck; Mahmood Alam; Andrew B. Tobin

doi:10.1016/j.micinf.2012.04.008

Insights into the Plasmodium falciparum schizont phospho-proteome

Edwin Lasonder^*, Moritz Treeck, Mahmood Alam, Andrew B. Tobin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

It is becoming clear that, as is the case with many human diseases, targeting protein phosphorylation in strategies aimed at developing the next generation of anti-malarials is likely to bear considerable fruit. A major barrier to this development, however, is the paucity of information regarding the role of protein phosphorylation in malaria. A major step has recently been taken in this area with the publication of the first analyses of the phospho-proteome of the most virulent species of human malaria Plasmodium falciparum. Here, we discuss these studies.

Original language	English
Pages (from-to)	811-819
Number of pages	9
Journal	Microbes and Infection
Volume	14
Issue number	10
Early online date	5 May 2012
DOIs	https://doi.org/10.1016/j.micinf.2012.04.008
Publication status	Published - 1 Aug 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Phospho-proteome
Plasmodium falciparum
Protein kinase
Schizont
Signalling
Toxoplasma gondii

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10.1016/j.micinf.2012.04.008

Cite this

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title = "Insights into the Plasmodium falciparum schizont phospho-proteome",

abstract = "It is becoming clear that, as is the case with many human diseases, targeting protein phosphorylation in strategies aimed at developing the next generation of anti-malarials is likely to bear considerable fruit. A major barrier to this development, however, is the paucity of information regarding the role of protein phosphorylation in malaria. A major step has recently been taken in this area with the publication of the first analyses of the phospho-proteome of the most virulent species of human malaria Plasmodium falciparum. Here, we discuss these studies.",

keywords = "Phospho-proteome, Plasmodium falciparum, Protein kinase, Schizont, Signalling, Toxoplasma gondii",

author = "Edwin Lasonder and Moritz Treeck and Mahmood Alam and Tobin, \{Andrew B.\}",

note = "Funding Information: The work carried for the Lasonder study was supported by MALSIG and EVIMALAR. MT was supported in parts by the German Research Foundation , the American Heart Foundation and the NIH ( AI09763301 ). The work by MA and ABT is supported by the Wellcome Trust ( 090313 ). We thank Christian Doerig, John Sanders and Josh Elias for critical reading and input and Christina Ludwig and Ruedi Aebersold for sharing unpublished results. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",

year = "2012",

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doi = "10.1016/j.micinf.2012.04.008",

language = "English",

volume = "14",

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T1 - Insights into the Plasmodium falciparum schizont phospho-proteome

AU - Lasonder, Edwin

AU - Treeck, Moritz

AU - Alam, Mahmood

AU - Tobin, Andrew B.

N1 - Funding Information: The work carried for the Lasonder study was supported by MALSIG and EVIMALAR. MT was supported in parts by the German Research Foundation , the American Heart Foundation and the NIH ( AI09763301 ). The work by MA and ABT is supported by the Wellcome Trust ( 090313 ). We thank Christian Doerig, John Sanders and Josh Elias for critical reading and input and Christina Ludwig and Ruedi Aebersold for sharing unpublished results. Copyright: Copyright 2012 Elsevier B.V., All rights reserved.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - It is becoming clear that, as is the case with many human diseases, targeting protein phosphorylation in strategies aimed at developing the next generation of anti-malarials is likely to bear considerable fruit. A major barrier to this development, however, is the paucity of information regarding the role of protein phosphorylation in malaria. A major step has recently been taken in this area with the publication of the first analyses of the phospho-proteome of the most virulent species of human malaria Plasmodium falciparum. Here, we discuss these studies.

AB - It is becoming clear that, as is the case with many human diseases, targeting protein phosphorylation in strategies aimed at developing the next generation of anti-malarials is likely to bear considerable fruit. A major barrier to this development, however, is the paucity of information regarding the role of protein phosphorylation in malaria. A major step has recently been taken in this area with the publication of the first analyses of the phospho-proteome of the most virulent species of human malaria Plasmodium falciparum. Here, we discuss these studies.

KW - Phospho-proteome

KW - Plasmodium falciparum

KW - Protein kinase

KW - Schizont

KW - Signalling

KW - Toxoplasma gondii

UR - https://www.scopus.com/pages/publications/84863855283

U2 - 10.1016/j.micinf.2012.04.008

DO - 10.1016/j.micinf.2012.04.008

M3 - Article

C2 - 22569589

AN - SCOPUS:84863855283

SN - 1286-4579

VL - 14

SP - 811

EP - 819

JO - Microbes and Infection

JF - Microbes and Infection

IS - 10

ER -

Insights into the Plasmodium falciparum schizont phospho-proteome

Abstract

UN SDGs

Keywords

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