TY - JOUR
T1 - Insulin resistance, age and depression's impact on cognition in middle-aged adults from the PREVENT cohort
AU - Bauermeister, Sarah D.
AU - Ben Yehuda, Michael
AU - Reid, Graham
AU - Howgego, Gregory
AU - Ritchie, Karen
AU - Watermeyer, Tam
AU - Gregory, Sarah
AU - Terrera, Graciela Muniz
AU - Koychev, Ivan
N1 - Funding information: The PREVENT study was funded by the Alzheimer's Society (grant numbers 178 and 264), the Alzheimer’s Association (grant number TriBEKa-17-519007) and philanthropic donations. GR acknowledges funding for this work for his research programme funded by the Medical Research council (Dementias Platform UK; MR/T033371/1) and Five Lives Ltd. IK declares funding for this project through Medical Research Council (Dementias Platform UK), NIHR Oxford Health Biomedical Research Centre and NIHR personal awards. SG acknowledges funding for salary from the Medical Research Council Nutrition Research Partnership Collaboration Award (MR/T001852/1).
PY - 2023/5/26
Y1 - 2023/5/26
N2 - BACKGROUND: Alzheimer's disease (AD), type 2 diabetes mellitus (characterised by insulin resistance) and depression are significant challenges facing public health. Research has demonstrated common comorbidities among these three conditions, typically focusing on two of them at a time. OBJECTIVE: The goal of this study, however, was to assess the inter-relationships between the three conditions, focusing on mid-life (defined as age 40-59) risk before the emergence of dementia caused by AD. METHODS: In the current study, we used cross-sectional data from 665 participants from the cohort study, PREVENT. FINDINGS: Using structural equation modelling, we showed that (1) insulin resistance predicts executive dysfunction in older but not younger adults in mid-life, that (2) insulin resistance predicts self-reported depression in both older and younger middle-aged adults and that (3) depression predicts deficits in visuospatial memory in older but not younger adults in mid-life. CONCLUSIONS: Together, we demonstrate the inter-relations between three common non-communicable diseases in middle-aged adults. CLINICAL IMPLICATIONS: We emphasise the need for combined interventions and the use of resources to help adults in mid-life to modify risk factors for cognitive impairment, such as depression and diabetes.
AB - BACKGROUND: Alzheimer's disease (AD), type 2 diabetes mellitus (characterised by insulin resistance) and depression are significant challenges facing public health. Research has demonstrated common comorbidities among these three conditions, typically focusing on two of them at a time. OBJECTIVE: The goal of this study, however, was to assess the inter-relationships between the three conditions, focusing on mid-life (defined as age 40-59) risk before the emergence of dementia caused by AD. METHODS: In the current study, we used cross-sectional data from 665 participants from the cohort study, PREVENT. FINDINGS: Using structural equation modelling, we showed that (1) insulin resistance predicts executive dysfunction in older but not younger adults in mid-life, that (2) insulin resistance predicts self-reported depression in both older and younger middle-aged adults and that (3) depression predicts deficits in visuospatial memory in older but not younger adults in mid-life. CONCLUSIONS: Together, we demonstrate the inter-relations between three common non-communicable diseases in middle-aged adults. CLINICAL IMPLICATIONS: We emphasise the need for combined interventions and the use of resources to help adults in mid-life to modify risk factors for cognitive impairment, such as depression and diabetes.
UR - http://www.scopus.com/inward/record.url?scp=85168600116&partnerID=8YFLogxK
U2 - 10.1136/bmjment-2023-300665
DO - 10.1136/bmjment-2023-300665
M3 - Article
C2 - 37236657
AN - SCOPUS:85168600116
SN - 2755-9734
VL - 26
SP - 1
EP - 6
JO - BMJ Mental Health
JF - BMJ Mental Health
IS - 1
M1 - e300665
ER -
