Integrating microfluidics and biosensing on a single flexible acoustic device using hybrid modes

Ran Tao, Julien Reboud, Hamdi Torun, Glen McHale, Linzi E Dodd, Qiang Wu, Xin Yang, Kai Tao, Jing Ting Luo, Stephen Todryk, Yong Qing Fu

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
27 Downloads (Pure)

Abstract

Integration of microfluidics and biosensing functionalities on a single device holds promise in continuous health monitoring and disease diagnosis for point-of-care applications. However, the required functions of fluid handling and biomolecular sensing usually arise from different actuation mechanisms. In this work, we demonstrate that a single acoustofluidic device, based on a flexible thin film platform, is able to generate hybrid waves modes, which can be used for fluidic actuation (Lamb waves) and biosensing (thickness shear waves). On this integrated platform, we show multiple and sequential functions of mixing, transport and disposal of liquid volumes using Lamb waves, whilst the thickness bulk shear waves allow us to sense the chemotherapeutic Imatinib, using an aptamer-based strategy, as would be required for therapy monitoring. Upon binding, the conformation of the aptamer results in a change in coupled mass, which has been detected. This platform architecture has the potential to generate a wide range of simple sample-to-answer biosensing acoustofluidic devices.
Original languageEnglish
Pages (from-to)1002-1011
Number of pages10
JournalLab on a Chip
Volume20
Issue number5
Early online date3 Feb 2020
DOIs
Publication statusPublished - 7 Mar 2020

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