Interval versus constant-load exercise training in adults with Cystic Fibrosis

Georgios Kaltsakas; Nikolaos Chynkiamis; Nikolaos Anastasopoulos; Pinelopi Zeliou; Vicky Karapatoucha; Kostantinos Kotsifas; Fotoula Diamantea; Ioannis Inglezos; Nikolaos Koulouris; Ioannis Vogiatzis

doi:10.1016/j.resp.2021.103643

Interval versus constant-load exercise training in adults with Cystic Fibrosis

Georgios Kaltsakas^*, Nikolaos Chynkiamis, Nikolaos Anastasopoulos, Pinelopi Zeliou, Vicky Karapatoucha, Kostantinos Kotsifas, Fotoula Diamantea, Ioannis Inglezos, Nikolaos Koulouris, Ioannis Vogiatzis^*

^*Corresponding author for this work

Sport Exercise and Rehabilitation Department

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

69 Downloads (Pure)

Abstract

Background:
The efficacy of interval exercise (IE) compared to constant-load exercise (CLE) training remains unsettled in adults with Cystic Fibrosis (CF).

Methods:
Twenty-four adults with CF were randomised to 30-min IE (100% peak work capacity (WRpeak) for 30-s alternated with 40% WRpeak for 30-s; n = 12) or 30-min CLE (70% WRpeak; n = 12) training, 3 times weekly, for 12 weeks. Isometric quadriceps muscle strength was assessed using a strain gauge Myometer.

Results:
The magnitude of improvement in quadriceps muscle strength was greater (p = 0.037) in the IE (by 32 ± 13 Nm) compared to the CLE (by 23 ± 12 Nm) groups. Maximum inspiratory and expiratory mouth pressures were significantly improved only in the IE group (by 30 ± 10 cmH2O; p = 0.009 and 13 ± 4 cmH2O; p = 0.007, respectively). Arterial oxygen saturation during training was higher (p = 0.002) for IE (94 ± 1%) compared to CLE (91 ± 1%), whereas dyspnoea scores were lower (p = 0.001) for IE (3.8 ± 0.7) compared to CLE (5.9 ± 0.8)

Conclusions:
IE is superior to CLE in improving peripheral and respiratory muscle strength and preferable to CLE because it is associated with lower exercise-induced arterial oxygen desaturation and breathlessness.

Original language	English
Article number	103643
Journal	Respiratory Physiology and Neurobiology
Volume	288
Early online date	19 Feb 2021
DOIs	https://doi.org/10.1016/j.resp.2021.103643
Publication status	Published - 1 Jun 2021

Keywords

Cystic Fibrosis
Pulmonary Rehabilitation
Interval Exercise
Physical Activity

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CF_manuscript_revised_clean_copy_1_Accepted author manuscript, 371 KBLicence: CC BY-NC-ND

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title = "Interval versus constant-load exercise training in adults with Cystic Fibrosis",

abstract = "Background: The efficacy of interval exercise (IE) compared to constant-load exercise (CLE) training remains unsettled in adults with Cystic Fibrosis (CF).Methods: Twenty-four adults with CF were randomised to 30-min IE (100% peak work capacity (WRpeak) for 30-s alternated with 40% WRpeak for 30-s; n = 12) or 30-min CLE (70% WRpeak; n = 12) training, 3 times weekly, for 12 weeks. Isometric quadriceps muscle strength was assessed using a strain gauge Myometer.Results: The magnitude of improvement in quadriceps muscle strength was greater (p = 0.037) in the IE (by 32 ± 13 Nm) compared to the CLE (by 23 ± 12 Nm) groups. Maximum inspiratory and expiratory mouth pressures were significantly improved only in the IE group (by 30 ± 10 cmH2O; p = 0.009 and 13 ± 4 cmH2O; p = 0.007, respectively). Arterial oxygen saturation during training was higher (p = 0.002) for IE (94 ± 1%) compared to CLE (91 ± 1%), whereas dyspnoea scores were lower (p = 0.001) for IE (3.8 ± 0.7) compared to CLE (5.9 ± 0.8) Conclusions: IE is superior to CLE in improving peripheral and respiratory muscle strength and preferable to CLE because it is associated with lower exercise-induced arterial oxygen desaturation and breathlessness.",

keywords = "Cystic Fibrosis, Pulmonary Rehabilitation, Interval Exercise, Physical Activity",

author = "Georgios Kaltsakas and Nikolaos Chynkiamis and Nikolaos Anastasopoulos and Pinelopi Zeliou and Vicky Karapatoucha and Kostantinos Kotsifas and Fotoula Diamantea and Ioannis Inglezos and Nikolaos Koulouris and Ioannis Vogiatzis",

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month = jun,

day = "1",

doi = "10.1016/j.resp.2021.103643",

language = "English",

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journal = "Respiratory Physiology and Neurobiology",

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TY - JOUR

T1 - Interval versus constant-load exercise training in adults with Cystic Fibrosis

AU - Kaltsakas, Georgios

AU - Chynkiamis, Nikolaos

AU - Anastasopoulos, Nikolaos

AU - Zeliou, Pinelopi

AU - Karapatoucha, Vicky

AU - Kotsifas, Kostantinos

AU - Diamantea, Fotoula

AU - Inglezos, Ioannis

AU - Koulouris, Nikolaos

AU - Vogiatzis, Ioannis

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Background: The efficacy of interval exercise (IE) compared to constant-load exercise (CLE) training remains unsettled in adults with Cystic Fibrosis (CF).Methods: Twenty-four adults with CF were randomised to 30-min IE (100% peak work capacity (WRpeak) for 30-s alternated with 40% WRpeak for 30-s; n = 12) or 30-min CLE (70% WRpeak; n = 12) training, 3 times weekly, for 12 weeks. Isometric quadriceps muscle strength was assessed using a strain gauge Myometer.Results: The magnitude of improvement in quadriceps muscle strength was greater (p = 0.037) in the IE (by 32 ± 13 Nm) compared to the CLE (by 23 ± 12 Nm) groups. Maximum inspiratory and expiratory mouth pressures were significantly improved only in the IE group (by 30 ± 10 cmH2O; p = 0.009 and 13 ± 4 cmH2O; p = 0.007, respectively). Arterial oxygen saturation during training was higher (p = 0.002) for IE (94 ± 1%) compared to CLE (91 ± 1%), whereas dyspnoea scores were lower (p = 0.001) for IE (3.8 ± 0.7) compared to CLE (5.9 ± 0.8) Conclusions: IE is superior to CLE in improving peripheral and respiratory muscle strength and preferable to CLE because it is associated with lower exercise-induced arterial oxygen desaturation and breathlessness.

AB - Background: The efficacy of interval exercise (IE) compared to constant-load exercise (CLE) training remains unsettled in adults with Cystic Fibrosis (CF).Methods: Twenty-four adults with CF were randomised to 30-min IE (100% peak work capacity (WRpeak) for 30-s alternated with 40% WRpeak for 30-s; n = 12) or 30-min CLE (70% WRpeak; n = 12) training, 3 times weekly, for 12 weeks. Isometric quadriceps muscle strength was assessed using a strain gauge Myometer.Results: The magnitude of improvement in quadriceps muscle strength was greater (p = 0.037) in the IE (by 32 ± 13 Nm) compared to the CLE (by 23 ± 12 Nm) groups. Maximum inspiratory and expiratory mouth pressures were significantly improved only in the IE group (by 30 ± 10 cmH2O; p = 0.009 and 13 ± 4 cmH2O; p = 0.007, respectively). Arterial oxygen saturation during training was higher (p = 0.002) for IE (94 ± 1%) compared to CLE (91 ± 1%), whereas dyspnoea scores were lower (p = 0.001) for IE (3.8 ± 0.7) compared to CLE (5.9 ± 0.8) Conclusions: IE is superior to CLE in improving peripheral and respiratory muscle strength and preferable to CLE because it is associated with lower exercise-induced arterial oxygen desaturation and breathlessness.

KW - Cystic Fibrosis

KW - Pulmonary Rehabilitation

KW - Interval Exercise

KW - Physical Activity

U2 - 10.1016/j.resp.2021.103643

DO - 10.1016/j.resp.2021.103643

M3 - Article

SN - 1569-9048

VL - 288

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

M1 - 103643

ER -

Interval versus constant-load exercise training in adults with Cystic Fibrosis

Abstract

Keywords

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