TY - JOUR
T1 - Investigation of the Effects of an Inferior Vena Cava Filter and Captured Clot Size on the Hemodynamic Parameters in Non-Newtonian Turbulent Pulsatile Blood Flow
AU - Moradicheghamahi, Jafar
AU - Qasim, Muhammad
AU - Jafarpour, Sohrab
AU - Farokhi, Hamed
N1 - Funding information: We would like to thank the Smart Technology for Smart Healthcare group of the University of Rovira and Virgili, Prof. Josep M. Lopez, Prof. Gerard Fortuny, Prof. Juan Herrero, and Prof. Dolors Puigjaner for sharing the geometry with us. Open access funding was enabled and organized by CRUE-CSUC Gold.
PY - 2023/10/31
Y1 - 2023/10/31
N2 - In this computational fluid dynamics (CFD)-based study, the effects of inferior vena cava (IVC) filter implantation on the risk of IVC thrombosis have been investigated using different hemodynamic parameters, including time-averaged wall shear stress (TAWSS), the oscillating shear index (OSI), and the relative residence time (RRT). The boundary conditions in this study have been based on physiological pulses. Additionally, the k–ω model and the Carreau model have been chosen to represent the turbulent flow regime and non-Newtonian blood, respectively. For this purpose, three blood clots with the largest cross-sectional diameters of 30%, 50%, and 70% of the filter diameter have been used. Capturing a small clot in the filter has the minimum effect on the hemodynamic parameters, while by increasing the size of the captured clot, OSI and RRT parameters increase in areas downstream of the filter on the wall. The presence of a filter and clot increases the risk of thrombosis. In the case of capturing large clots, there is the possibility of damage to endothelial cells or platelet activation. Captured clots lead to the formation of plaque and thrombus on the IVC wall. However, the possibility of thrombus growth on its surface is not negligible, particularly if larger clots are trapped in the filter.
AB - In this computational fluid dynamics (CFD)-based study, the effects of inferior vena cava (IVC) filter implantation on the risk of IVC thrombosis have been investigated using different hemodynamic parameters, including time-averaged wall shear stress (TAWSS), the oscillating shear index (OSI), and the relative residence time (RRT). The boundary conditions in this study have been based on physiological pulses. Additionally, the k–ω model and the Carreau model have been chosen to represent the turbulent flow regime and non-Newtonian blood, respectively. For this purpose, three blood clots with the largest cross-sectional diameters of 30%, 50%, and 70% of the filter diameter have been used. Capturing a small clot in the filter has the minimum effect on the hemodynamic parameters, while by increasing the size of the captured clot, OSI and RRT parameters increase in areas downstream of the filter on the wall. The presence of a filter and clot increases the risk of thrombosis. In the case of capturing large clots, there is the possibility of damage to endothelial cells or platelet activation. Captured clots lead to the formation of plaque and thrombus on the IVC wall. However, the possibility of thrombus growth on its surface is not negligible, particularly if larger clots are trapped in the filter.
U2 - 10.1155/2023/2439775
DO - 10.1155/2023/2439775
M3 - Article
SN - 1176-2322
VL - 2023
SP - 1
EP - 18
JO - Applied Bionics and Biomechanics
JF - Applied Bionics and Biomechanics
M1 - 2439775
ER -