Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes

Valery N Kozhevnikov, Michael E Deary, Theodora Mantso, Mihalis I Panayiotidis, Mark T Sims

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
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Abstract

In this paper we describe unprecedented Ir(III) complexes of 5-(2-pyridyl)-1,2,4-triazine and their reactivity towards the strained cyclooctyne BCN. The coordination of a 1,2,4-triazine ring to an iridium(III) ion drastically increases the speed of the reaction, showing the second order rate constant of 8 M−1 s−1, the record value to date for a triazine-BCN reaction.
Original languageEnglish
Pages (from-to)14283-14286
Number of pages4
JournalChemical Communications
Volume55
Issue number95
Early online date1 Nov 2019
DOIs
Publication statusPublished - 11 Dec 2019

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