Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes

Valery N Kozhevnikov; Michael E Deary; Theodora Mantso; Mihalis I Panayiotidis; Mark T Sims

doi:10.1039/C9CC06828G

Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes

Valery N Kozhevnikov, Michael E Deary, Theodora Mantso, Mihalis I Panayiotidis, Mark T Sims

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Abstract

In this paper we describe unprecedented Ir(III) complexes of 5-(2-pyridyl)-1,2,4-triazine and their reactivity towards the strained cyclooctyne BCN. The coordination of a 1,2,4-triazine ring to an iridium(III) ion drastically increases the speed of the reaction, showing the second order rate constant of 8 M−1 s−1, the record value to date for a triazine-BCN reaction.

Original language	English
Pages (from-to)	14283-14286
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	95
Early online date	1 Nov 2019
DOIs	https://doi.org/10.1039/C9CC06828G
Publication status	Published - 11 Dec 2019

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abstract = "In this paper we describe unprecedented Ir(III) complexes of 5-(2-pyridyl)-1,2,4-triazine and their reactivity towards the strained cyclooctyne BCN. The coordination of a 1,2,4-triazine ring to an iridium(III) ion drastically increases the speed of the reaction, showing the second order rate constant of 8 M−1 s−1, the record value to date for a triazine-BCN reaction.",

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AU - Kozhevnikov, Valery N

AU - Deary, Michael E

AU - Mantso, Theodora

AU - Panayiotidis, Mihalis I

AU - Sims, Mark T

PY - 2019/12/11

Y1 - 2019/12/11

N2 - In this paper we describe unprecedented Ir(III) complexes of 5-(2-pyridyl)-1,2,4-triazine and their reactivity towards the strained cyclooctyne BCN. The coordination of a 1,2,4-triazine ring to an iridium(III) ion drastically increases the speed of the reaction, showing the second order rate constant of 8 M−1 s−1, the record value to date for a triazine-BCN reaction.

AB - In this paper we describe unprecedented Ir(III) complexes of 5-(2-pyridyl)-1,2,4-triazine and their reactivity towards the strained cyclooctyne BCN. The coordination of a 1,2,4-triazine ring to an iridium(III) ion drastically increases the speed of the reaction, showing the second order rate constant of 8 M−1 s−1, the record value to date for a triazine-BCN reaction.

U2 - 10.1039/C9CC06828G

DO - 10.1039/C9CC06828G

M3 - Article

SN - 1359-7345

VL - 55

SP - 14283

EP - 14286

JO - Chemical Communications

JF - Chemical Communications

IS - 95

ER -

Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes

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