TY - JOUR
T1 - Iridium(iii) complexes of 1,2,4-triazines as potential bioorthogonal reagents: metal coordination facilitates luminogenic reaction with strained cyclooctynes
AU - Kozhevnikov, Valery N
AU - Deary, Michael E
AU - Mantso, Theodora
AU - Panayiotidis, Mihalis I
AU - Sims, Mark T
PY - 2019/12/11
Y1 - 2019/12/11
N2 - In this paper we describe unprecedented Ir(III) complexes of 5-(2-pyridyl)-1,2,4-triazine and their reactivity towards the strained cyclooctyne BCN. The coordination of a 1,2,4-triazine ring to an iridium(III) ion drastically increases the speed of the reaction, showing the second order rate constant of 8 M−1 s−1, the record value to date for a triazine-BCN reaction.
AB - In this paper we describe unprecedented Ir(III) complexes of 5-(2-pyridyl)-1,2,4-triazine and their reactivity towards the strained cyclooctyne BCN. The coordination of a 1,2,4-triazine ring to an iridium(III) ion drastically increases the speed of the reaction, showing the second order rate constant of 8 M−1 s−1, the record value to date for a triazine-BCN reaction.
UR - https://www.scopus.com/pages/publications/85075647390
U2 - 10.1039/C9CC06828G
DO - 10.1039/C9CC06828G
M3 - Article
SN - 1359-7345
VL - 55
SP - 14283
EP - 14286
JO - Chemical Communications
JF - Chemical Communications
IS - 95
ER -