Iron-catalyzed cross-coupling between 1-Bromoalkynes and Grignard-derived organocuprate reagents

Daniele Castagnolo, Maurizio Botta

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes
Original languageEnglish
Pages (from-to)3224-3228
JournalEuropean Journal of Organic Chemistry
Volume2010
Issue number17
DOIs
Publication statusPublished - 2010

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