Abstract
An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of alkynylarenes
Original language | English |
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Pages (from-to) | 3224-3228 |
Journal | European Journal of Organic Chemistry |
Volume | 2010 |
Issue number | 17 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- alkynes
- Iron
- Grignard reagents
- homogeneous catalysis